151072-06-9

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 155-30-6 methyl 1-thio-β-D-galactopyranoside 
• 100288-60-6 tert-butyldiphenylsilyl ether 

Downstream Products

• 151072-08-1 methyl 6-O-(tert-butyldiphenylsilyl)-3,4-O-isopropylidene-2-O-(4-methoxybenzyl)-1-thio-β-D-galactopyranoside 
• 146582-13-0 methyl 3,4-O-isopropylidene-2-O-(4-methoxybenzyl)-1-thio-β-D-galactopyranoside 
• 146578-30-5 Methyl 2-O-(4-methoxybenzyl)-1-thio-β-D-galactopyranoside 
• 244022-43-3 methyl 6-O-tert-butyldiphenylsilyl-2,3,4-tri-O-(4-methylbenzoyl)-1-thio-β-D-galactopyranoside 
• 151072-07-0 methyl 6-O-(tert-butyldiphenylsilyl)-3,4-O-isopropylidene-1-thio-β-D-galactopyranoside 

Relevant academic research and scientific papers

Stereoselective syntheses of phosphorylated and sulfated glycosyl serines in glycosaminoglycan for biological probes

Phosphorylated glycosyl serines of glycosaminoglycan with/without sulfate: β-D-Xyl(2P)-Ser (1) and β-D-Gal(±6S)-(1→4)-β-D-Xyl(2P)-Ser (2, 3) were suitably designed for biological probes. These oligosaccharides were synthesized in a stereocontrolled manner.

Protecting groups for carbohydrate synthesis

The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal protection strategy all

Synthesis of phosphorylated and sulfated glycosyl serines in the linkage region of the glycosaminoglycans

We synthesized novel acidic glycans having acidic groups located in the linkage region of the glycosaminoglycans (GAGs). The targeted compounds, β-D-Xyl(2P)-Ser (1), β-D-Gal(±6S)-(1→4)-β-D-Xyl(2P)-Ser (3 and 2), β-D-Gal(±6S)-(1→3)-β-D-Gal- (1→4)-β-D-Xyl(2P)-Ser (5 and 4), and β-D-Gal-(1→3)-β-D-Gal(6S)-(1→4)-β-D-Xyl(2P)-Ser (6) contain phosphate and/or sulfate at the specified positions. Some of them (3, 5, and 6) are the first synthesized examples of natural-type glycoconjugates that simultaneously possess phosphate and sulfate as well as carboxylic acid.

Synthesis of a tetrasaccharide donor corresponding to the O-specific polysaccharide of Shigella dysenteriae type 1

O-(2,4-Di-O-benzoyl-3-O-chloroacetyl-α-L-rhamnopyranosyl)-(1 → 2)-O-(3,4,6-tri-O-benzoyl-α-D-galactopyranosyl)-(1 → 3)-O-(2-acetamido-4,6-di-O-acetyl-2-deoxy-α-D-glucopyranosyl)-(1 → 3)-2,4-di-O-benzoyl-α-L-rhamnopyranosyl trichloroacetimidate (1) was syn