1003-07-2

Basic information

• Product Name: thiazol-3-one
• Synonyms: thiazol-3-one;3-isothiazolone;Isothiazol-3-one;1,2-thiazol-3-one;3(2H)-Isothiazolone;3-Oxo-2,3-dihydroisothiazole;Isothiazol-3(2H)-one;3-Hydroxyisothiazole, 2,3-Dihydro-3-oxoisothiazole, 1,2-Thiazol-3(2H)-one
• CAS NO: 1003-07-2
• Molecular Formula: C₃H₃NOS
• Molecular Weight: 101.13
• Product Categories: organic building block
• Mol File: 1003-07-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 74-75 °C
• Boiling Point: 86.333 °C at 760 mmHg
• Flash Point: 6.014 °C
• Appearance: /
• Density: 1.433 g/cm³
• Vapor Pressure: 59.568mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 9.12±0.20(Predicted)
• CAS DataBase Reference: thiazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: thiazol-3-one(1003-07-2)
• EPA Substance Registry System: thiazol-3-one(1003-07-2)

Safety Data

• Hazardous Substances Data: 1003-07-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 2660, 1965 DOI: 10.1021/jo01019a037

InChI:InChI=1/C3H3NOS/c5-3-1-2-6-4-3/h1-2H,(H,4,5)

Upstream product

• 2807-36-5 cis-3-Thiocyano-acrylamid 
• 2682-21-5 N-ethylisothiazol-3(2H)-one 
• 1668-10-6 glycinamide hydrochloride 
• 1002-19-3 3,3'-disulfanediylpropanamide 

Downstream Products

• 42828-61-5 2-(4-chloro-anilinomethyl)-isothiazol-3-one 
• 42828-69-3 2-benzoyl-isothiazol-3-one 
• 1213258-34-4 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-phenyloxazolidin-2-one 
• 1213258-35-5 3-(4-fluorophenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 1213258-36-6 3-(3-fluorophenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 1213258-37-7 3-(4-chlorophenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 1213258-38-8 3-(3-chlorophenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 1213258-40-2 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-p-tolyloxazolidin-2-one 
• 1213258-41-3 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-(4-(trifluoromethyl)phenyl)oxazolidin-2-one 
• 1213258-43-5 3-benzyl-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 1213258-39-9 3-(4-methoxyphenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 1213258-44-6 3-(4-acetylphenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 1213258-42-4 3-(3-fluoro-4-morpholinophenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 60666-83-3 3-benzyloxyisothiazole 

Relevant articles and documents

Imidazolo-5-YL-2anilino-pyrimidines as agents for the inhibition of the cell proliffration

Compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

Isothiazolones

Isothiazolones having the general structure STR1 where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R1 and R2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.

Nitrosamine-free 3-isothiazolone

Nitrosamine-free 3-isothiazolone biocidal compositions suitable for applications where substantial human or animal contact is anticipated, their method of use and process of preparation are disclosed.