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(+/-)-HA-966 is a chemical compound that functions as a selective antagonist of the N-methyl-D-aspartate (NMDA) receptor, playing a crucial role in synaptic transmission and plasticity. It inhibits the binding of the neurotransmitter glutamate to the NMDA receptor, thus reducing its activation. This modulation of excitatory neurotransmission positions (+/-)-HA-966 as a potential therapeutic agent for neurological disorders and neuroprotection against excitotoxic neuronal damage.

1003-51-6

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1003-51-6 Hazards Identification

Pictogram(s):

Signal:

Warning

GHS Hazard Statements:

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statement Codes:

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories:

Skin Irrit. 2 (100%)
Eye Irrit. 2A (100%)
STOT SE 3 (100%)

1003-51-6 Usage

Uses

Used in Pharmaceutical Industry:
(+/-)-HA-966 is used as a therapeutic agent for the treatment of neurological disorders such as epilepsy and chronic pain. Its ability to modulate excitatory neurotransmission makes it a promising candidate for managing conditions characterized by excessive neuronal activity.
Used in Neuroprotection Research:
(+/-)-HA-966 is utilized in neuroprotective applications aimed at preventing neuronal damage caused by excitotoxicity. Its potential to protect neurons from damage makes it a valuable compound in the development of treatments for conditions associated with neurodegeneration.
Used in Drug Development:
(+/-)-HA-966 serves as a key compound in the development of novel medications targeting NMDA receptor function. Its selective antagonism of the NMDA receptor offers a pathway to explore new treatment options for a range of neurological conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1003-51-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,0 and 3 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1003-51:
(6*1)+(5*0)+(4*0)+(3*3)+(2*5)+(1*1)=26
26 % 10 = 6
So 1003-51-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2/t3-/m0/s1

1003-51-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Amino-1-hydroxypyrrolidin-2-one

1.2 Other means of identification

Product number -
Other names 1-dodecyl-hexahydro-azepin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1003-51-6 SDS

1003-51-6Upstream product

1003-51-6Relevant academic research and scientific papers

ETHYNYLBENZENE DERIVATIVES

-

Page/Page column 47, (2012/03/26)

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

[3R]-3-amino-1-hydroxy pyrrolidin-2-one and its use as a neuroprotective agent

-

, (2008/06/13)

The present invention provides R(+)-3-amino-1-hydroxypyrrolidin-2-one of formula I: STR1 or pharmaceutically acceptable acid addition salt thereof, which compound is useful as an anticonvulsant agent and in the treatment and/or prevention of neurodegenerative disorders.

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