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| CAS No.: | 1003-51-6 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Name: | (+/-)-HA-966 | ||||||||
| Article Data: | 6 | ||||||||
| Molecular Structure: | |||||||||
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| Formula: | C4H8 N2 O2 | ||||||||
| Molecular Weight: | 116.12 | ||||||||
| Synonyms: | (?à)-HA 966;1-Hydroxy-3-amino-2-pyrrolidone;1-Hydroxy-3-aminopyrrolidin-2-one;3-Amino-1-hydroxy-2-pyrrolidone;3-Amino-1-hydroxypyrrolidone;DL-1-Hydroxy-3-amino-2-pyrrolidinone;HA 966; | ||||||||
| Density: | 1.436g/cm3 | ||||||||
| Melting Point: | 184 oC | ||||||||
| Boiling Point: | 258.6°Cat760mmHg | ||||||||
| Flash Point: | 110.2°C | ||||||||
| Appearance: | white crystalline powder | ||||||||
| Hazard Symbols: |
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| Risk Codes: | 36/37/38 | ||||||||
| Safety: |
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| PSA: | 66.56000 | ||||||||
| LogP: | -0.42660 | ||||||||
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- Total:28 Page 1 of 1 1
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Safety Profile
| Safety Statements: | S26 |
|---|---|
| HS Code: | 2933790090 |
| Risk Statements: | R36/37/38 |
| Hazard Codes: | Xi |
Specification
HA-966 or (±) 3-Amino-1-hydroxy-pyrrolidin-2-one is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist / low efficacy partial agonist. It has neuroprotective and anticonvulsant, anxiolytic, antinociceptive and sedative / hypnotic effects in animal models. Pilot human clinical trials in the early 1960s showed that HA-966 appeared to benefit patients with tremors of extrapyramidal origin.
The two enantiomers of HA-966 have differing pharmacological activity. The glycine/N-methyl-D-aspartate receptor antagonist activity is specific to the R-(+) enantiomer, whereas the sedative and ataxic effects are specific to the S-(-) enantiomer.
R-(+)-HA-966 did not induce drug-appropriate responding in animals trained to discriminate phencyclidine (PCP) from saline, suggesting that the glycine receptor ligand R-(+)-HA-966 has a significantly different behavioral profile than drugs affecting the ion channel of the NMDA receptor complex.
S-(−)-HA-966 has been described as a "γ-hydroxybutyric acid (GHB)-like agent" and a "potent y-butyrolactone-like sedative", but it shows no affinity for the GABAB receptor (GABABR).