100313-75-5

Basic information

• Product Name: 2-acetoxy-4-nitro-benzoyl chloride
• Synonyms: 2-acetoxy-4-nitro-benzoyl chloride
• CAS NO: 100313-75-5
• Molecular Weight: 243.603
• Mol File: 100313-75-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-acetoxy-4-nitro-benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetoxy-4-nitro-benzoyl chloride(100313-75-5)
• EPA Substance Registry System: 2-acetoxy-4-nitro-benzoyl chloride(100313-75-5)

Safety Data

• Hazardous Substances Data: 100313-75-5(Hazardous Substances Data)

Upstream product

• 619-19-2 2-hydroxy-4-nitrobenzoic acid 
• 17336-10-6 2-acetoxy-4-nitrobenzoic acid 

Downstream Products

• 857756-46-8 2-hydroxy-4-nitro-benzoic acid pyrimidin-2-ylamide 
• 279215-22-4 N-(4-cyano-phenyl)-2,N-dihydroxy-4-nitro-benzamide 
• 2912-77-8 2-hydroxy-4-nitrobenzamide 
• 132984-48-6 4-(2-acetoxy-4-amino-benzoylamino)-2-hydroxy-benzoic acid 
• 99056-53-8 (2-acetoxy-4-amino-benzoyl)-urea 
• 101265-09-2 4-amino-2-hydroxy-benzoic acid cyclohexylamide 
• 859479-64-4 4-(2-hydroxy-4-nitro-phenyl)-thiazole-2-carboxylic acid ethyl ester 
• 855626-73-2 acetic acid-(5-nitro-2-thiazol-4-yl-phenyl ester) 
• 669092-56-2 2-(2-amino-thiazol-4-yl)-5-nitro-phenol 
• 99185-78-1 4-amino-2-hydroxy-benzoic acid thiazol-2-ylamide 
• 78154-70-8 4-(4-amino-2-hydroxy-benzoyl)-morpholine 
• 78154-71-9 1-(4-amino-2-hydroxy-benzoyl)-piperidine 

Relevant articles and documents

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface

Autophagy is the common name for a number of lysosome-based degradation pathways of cytosolic cargos. The key components of autophagy are members of Atg8 family proteins involved in almost all steps of the process, from autophagosome formation to their selective fusion with lysosomes. In this study, we show that the homologous members of the human Atg8 family proteins, LC3A and LC3B, are druggable by a small molecule inhibitor novobiocin. Structure-activity relationship (SAR) studies of the 4-hydroxy coumarin core scaffold were performed, supported by a crystal structure of the LC3A dihydronovobiocin complex. The study reports the first nonpeptide inhibitors for these protein interaction targets and will lay the foundation for the development of more potent chemical probes for the Atg8 protein family which may also find applications for the development of autophagy-mediated degraders (AUTACs).

The first general synthesis of N-substituted 1,2-benzisoxazolin-3-ones

A convenient synthesis of the title compounds has been developed. Key synthetic steps include: (1) conversion of the readily available salicylic acid derivatives to the corresponding N-substituted salicylhydroxamic acids; (2) cyclization of the hydroxamic acids under Mitsunobu conditions to give the title compounds. (C) 2000 Elsevier Science Ltd.