17336-10-6

Basic information

• Product Name: 2-(acetyloxy)-4-nitrobenzoic acid
• CAS NO: 17336-10-6
• Molecular Formula: C₉H₇NO₆
• Molecular Weight: 225.155
• Mol File: 17336-10-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 404°C at 760 mmHg
• Flash Point: 198.1°C
• Density: 1.486g/cm³
• Vapor Pressure: 2.98E-07mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 2-(acetyloxy)-4-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(acetyloxy)-4-nitrobenzoic acid(17336-10-6)
• EPA Substance Registry System: 2-(acetyloxy)-4-nitrobenzoic acid(17336-10-6)

Safety Data

• Hazardous Substances Data: 17336-10-6(Hazardous Substances Data)

Usage

Explanation

This is the chemical name of the compound, which is derived from its structural formula and functional groups.

Explanation

These are the common names for the compound, which are more widely recognized and used in everyday language.

Explanation

This indicates that the compound belongs to a specific group of organic compounds, which share a common structure and properties.

Explanation

This describes the primary therapeutic application of the compound, which is to alleviate pain and lower body temperature in cases of fever.

Explanation

This explains how the compound exerts its therapeutic effect, by preventing the formation of certain chemicals in the body that are responsible for pain and inflammation.

Explanation

This highlights other potential health benefits of the compound, beyond its primary use as a pain reliever and fever reducer.

Explanation

These are potential adverse effects that may occur as a result of using the compound, which can cause harm to the user.

Explanation

This advises users to seek professional medical advice before using the compound, in order to minimize the risk of side effects and ensure its safe and effective use.

Chemical class

Benzoic acids and derivatives

Main use

Pain reliever and fever reducer

Mechanism of action

Inhibits production of pain and inflammation-causing substances

Additional use

Reducing risk of heart attacks and strokes, treating circulatory conditions

Side effects

Stomach bleeding and ulcers

Caution and guidance

Use under the supervision of a healthcare professional

Upstream product

• 619-19-2 2-hydroxy-4-nitrobenzoic acid 
• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 279215-22-4 N-(4-cyano-phenyl)-2,N-dihydroxy-4-nitro-benzamide 
• 129175-81-1 (S)-2-(2-Acetoxy-4-amino-benzoylamino)-pentanedioic acid diethyl ester 
• 112888-94-5 (S)-2-(2-Acetoxy-4-prop-2-ynylamino-benzoylamino)-pentanedioic acid diethyl ester 
• 129175-85-5 (S)-2-(2-Acetoxy-4-nitro-benzoylamino)-pentanedioic acid diethyl ester 
• 112888-31-0 (S)-2-{2-Hydroxy-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid 
• 129175-56-0 (S)-2-{2-Acetoxy-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid diethyl ester 
• 717912-55-5 1-(2-acetoxy-4-nitro-phenyl)-2-chloro-ethanone 
• 859479-64-4 4-(2-hydroxy-4-nitro-phenyl)-thiazole-2-carboxylic acid ethyl ester 
• 855626-73-2 acetic acid-(5-nitro-2-thiazol-4-yl-phenyl ester) 
• 669092-56-2 2-(2-amino-thiazol-4-yl)-5-nitro-phenol 
• 108950-15-8 2-hydroxy-4-(2-hydroxy-4-nitro-benzoylamino)-benzoic acid 
• 874501-34-5 2-acetoxy-4-nitro-benzoic acid p-toluidide 
• 109507-26-8 4-(4-amino-2-hydroxy-benzoylamino)-2-hydroxy-benzoic acid 
• 875815-10-4 1-(2-acetoxy-4-nitro-phenyl)-2-diazo-ethanone 

Relevant articles and documents

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface

Autophagy is the common name for a number of lysosome-based degradation pathways of cytosolic cargos. The key components of autophagy are members of Atg8 family proteins involved in almost all steps of the process, from autophagosome formation to their selective fusion with lysosomes. In this study, we show that the homologous members of the human Atg8 family proteins, LC3A and LC3B, are druggable by a small molecule inhibitor novobiocin. Structure-activity relationship (SAR) studies of the 4-hydroxy coumarin core scaffold were performed, supported by a crystal structure of the LC3A dihydronovobiocin complex. The study reports the first nonpeptide inhibitors for these protein interaction targets and will lay the foundation for the development of more potent chemical probes for the Atg8 protein family which may also find applications for the development of autophagy-mediated degraders (AUTACs).