100318-16-9Relevant academic research and scientific papers
N2-Alkylation of semicarbazones. A general and efficient protocol for the synthesis of 2-alkylsemicarbazides from semicarbazide
Fesenko, Anastasia A.,Trafimova, Ludmila A.,Zimin, Maxim O.,Kuvakin, Alexander S.,Shutalev, Anatoly D.
, p. 176 - 189 (2020/02/13)
Synthesis of 2-alkylsemicarbazones based on selective N2-alkylation of semicarbazones has been described. The synthesis involves deprotonation of semicarbazones with sodium hydride in MeCN followed by treatment with alkylating reagents. The developed alkylation method was applied to the preparation of hardly available 2-alkylsemicarbazides and their hydrochlorides from semicarbazide hydrochloride. This general and efficient protocol is based on preparation of acetone semicarbazone, its alkylation, and hydrolysis under mild conditions.
