100347-96-4

Basic information

• Product Name: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one
• Synonyms: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one;Curcumenone
• CAS NO: 100347-96-4
• Molecular Formula: C15H22O2
• Molecular Weight: 234.33398
• Mol File: 100347-96-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 343.7°C at 760 mmHg
• Flash Point: 128.9°C
• Appearance: /
• Density: 1.036g/cm³
• Vapor Pressure: 6.93E-05mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one(100347-96-4)
• EPA Substance Registry System: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one(100347-96-4)

Safety Data

• Hazardous Substances Data: 100347-96-4(Hazardous Substances Data)

Usage

Hazard

A poison.

InChI:InChI=1/C15H22O2/c1-9(2)11-7-13-12(6-5-10(3)16)15(13,4)8-14(11)17/h12-13H,5-8H2,1-4H3/t12-,13-,15+/m1/s1

Upstream product

• 6902-91-6 germacrone 
• 32179-17-2 (4S,5S)-(+)-germacrone 4,5-epoxide 

Downstream Products

• 213746-16-8 curcarabranol A 
• 213746-16-8 curcarabranol B 
• 142717-57-5 dihydrocurcumenone 
• 142717-60-0 (1S,6R,7R)-7-(3-Hydroxy-butyl)-4-(1-hydroxy-1-methyl-ethyl)-1-methyl-bicyclo[4.1.0]hept-4-en-3-one 
• 142717-59-7 (1S,6R,7R)-4-(1-Hydroxy-1-methyl-ethyl)-1-methyl-7-(3-oxo-butyl)-bicyclo[4.1.0]hept-4-en-3-one 

Relevant articles and documents

Absolute stereostructure of carabrane-type sesquiterpene and vasorelaxant-active sesquiterpenes from Zedoariae Rhizoma

The aqueous acetone extract of Zedoariae Rhizoma was found to show inhibitory effects on contractions induced by high concentrations of potassium cation (K+) in isolated rat aortic strips. From the extract, two new carabrane-type sesquiterpenes

Structural determination of two new sesquiterpenes biotransformed from germacrone by Mucor alternata

Eight transformed sesquiterpenes of germacrone by Mucor alternata were obtained. Their structures were characterized on the basis of spectral methods including 2D NMR. Among them, (1S, 4S, 55, 10R)-isozedoarondiol (2) and (1R, 4S, 55, 10R)-diepoxy-12-hydroxygermacrone (3) are new compounds. Copyright

BIOTRANSFORMATION OF SESQUITERPENES BY CULTURED CELLS OF CURCUMA ZEDOARIA

The transformation of a 10-membered ring sesquiterpene, germacrone, into guaiane-type sesquiterpenes by suspension cultured cells of Curcuma zedoaria was investigated.Germacrone was converted into several sesquiterpenes, some of which were isolated from the Curcuma spp. plants through the key intermediate, (4R,5R)-germacrone 4,5-epoxide, and their structures were determined by spectral and chemical evidence.The configurations of some of the derivatives were opposite to those of the sesquiterpenes isolated from the Curcuma sp plants, C. aromatica, C. longa and C. zedoaria.An eudesmane-type product was also isolated and its structur e was determined.From the structure, the transformation of germacrone through the intermediate, (1S,10S)-germacrone 1,10-epoxide, was supposed and further confirmed by the transformation of germacrone 1,10-epoxide into the same product by acid treatment.The structures of two new products were also determined and their transformation mechanism through curcumenone and dihydrocurcumenone was deduced. Key Word Index - Curcuma zedoaria; Zingiberaceae; cell suspension culture; biotransformation; sesquiterpene; germacrone; guaiane; eudesmane.