100347-96-4

Basic information

• Product Name: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one
• Synonyms: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one;Curcumenone
• CAS NO: 100347-96-4
• Molecular Formula: C15H22O2
• Molecular Weight: 234.33398
• Mol File: 100347-96-4.mol

Chemical Properties

• Boiling Point: 343.7°C at 760 mmHg
• Flash Point: 128.9°C
• Appearance: /
• Density: 1.036g/cm³
• Vapor Pressure: 6.93E-05mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one(100347-96-4)
• EPA Substance Registry System: (1S,6β)-1β-Methyl-4-(1-methylethylidene)-7β-(3-oxobutyl)bicyclo[4.1.0]heptan-3-one(100347-96-4)

Safety Data

• Hazardous Substances Data: 100347-96-4(Hazardous Substances Data)

Usage

Hazard

A poison.

InChI:InChI=1/C15H22O2/c1-9(2)11-7-13-12(6-5-10(3)16)15(13,4)8-14(11)17/h12-13H,5-8H2,1-4H3/t12-,13-,15+/m1/s1

Upstream product

• 6902-91-6 germacrone 
• 32179-17-2 (4S,5S)-(+)-germacrone 4,5-epoxide 

Downstream Products

• 213746-16-8 curcarabranol A 
• 213746-16-8 curcarabranol B 
• 142717-57-5 dihydrocurcumenone 
• 142717-60-0 (1S,6R,7R)-7-(3-Hydroxy-butyl)-4-(1-hydroxy-1-methyl-ethyl)-1-methyl-bicyclo[4.1.0]hept-4-en-3-one 
• 142717-59-7 (1S,6R,7R)-4-(1-Hydroxy-1-methyl-ethyl)-1-methyl-7-(3-oxo-butyl)-bicyclo[4.1.0]hept-4-en-3-one 

Relevant articles and documents

Absolute stereostructure of carabrane-type sesquiterpene and vasorelaxant-active sesquiterpenes from Zedoariae Rhizoma

The aqueous acetone extract of Zedoariae Rhizoma was found to show inhibitory effects on contractions induced by high concentrations of potassium cation (K+) in isolated rat aortic strips. From the extract, two new carabrane-type sesquiterpenes

Absolute stereostructures of carabrane-type sesquiterpenes, curcumenone, 4S-dihydrocurcumenone, and curcarabranols A and B: Vasorelaxant activity of Zedoary sesquiterpenes

New carabrane-type sesquiterpenes, curcarabranols A and B, were isolated from zedoary together with the two known carabrane-type sesquiterpenes curcumenone and 4S-dihydrocurcumenone. The absolute stereostructures of these carabrane-type sesquiterpenes were determined on the basis of physicochemical and chemical evidence. Zedoary sesquiterpenes including 4S-dihydrocurcumenone and curcarabranols A and B were found to inhibit the contraction induced by a high concentration of K+ in isolated rat aortic strips.

Structural determination of two new sesquiterpenes biotransformed from germacrone by Mucor alternata

Eight transformed sesquiterpenes of germacrone by Mucor alternata were obtained. Their structures were characterized on the basis of spectral methods including 2D NMR. Among them, (1S, 4S, 55, 10R)-isozedoarondiol (2) and (1R, 4S, 55, 10R)-diepoxy-12-hydroxygermacrone (3) are new compounds. Copyright

BIOTRANSFORMATION OF GERMACRONE BY SUSPENSION CULTURED CELLS

The transformation of germacrone, a 10-membered ring sesquiterpene, by suspension cultured cells of Lonicera japonica, Bupleurum falcatum, Polygonum tinctorium and Solidago altissima, was investigated.Germacrone was converted into several types of sesquiterpenes, such as guaiane, eudesman and seco-guaiane and their structures were determined from spectral and chemical evidence.The configurations of some of the products were determined by CD spectroscopy.The differences of the kinds of products among the four suspension cultured cells is discussed.

BIOTRANSFORMATION OF SESQUITERPENES BY CULTURED CELLS OF CURCUMA ZEDOARIA

The transformation of a 10-membered ring sesquiterpene, germacrone, into guaiane-type sesquiterpenes by suspension cultured cells of Curcuma zedoaria was investigated.Germacrone was converted into several sesquiterpenes, some of which were isolated from the Curcuma spp. plants through the key intermediate, (4R,5R)-germacrone 4,5-epoxide, and their structures were determined by spectral and chemical evidence.The configurations of some of the derivatives were opposite to those of the sesquiterpenes isolated from the Curcuma sp plants, C. aromatica, C. longa and C. zedoaria.An eudesmane-type product was also isolated and its structur e was determined.From the structure, the transformation of germacrone through the intermediate, (1S,10S)-germacrone 1,10-epoxide, was supposed and further confirmed by the transformation of germacrone 1,10-epoxide into the same product by acid treatment.The structures of two new products were also determined and their transformation mechanism through curcumenone and dihydrocurcumenone was deduced. Key Word Index - Curcuma zedoaria; Zingiberaceae; cell suspension culture; biotransformation; sesquiterpene; germacrone; guaiane; eudesmane.