1003575-43-6

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-4-fluorophenylboronic acid, pinacol ester is used as a reactant for the preparation of LY3009120, a pan-RAF inhibitor. 3-Amino-4-fluorophenylboronic acid, pinacol ester exhibits activity against BRAF or RAS mutant tumor cells, making it a valuable tool in the development of targeted cancer therapies. Its role in the synthesis of LY3009120 highlights its importance in the creation of novel and effective treatments for various types of cancer.

Upstream product

• 348-54-9 2-Fluoroaniline 
• 73183-34-3 bis(pinacol)diborane 
• 2924-09-6 5-bromo-2-fluoroaniline 
• 2106-05-0 5-chloro-2-fluoroaniline 
• 1218791-09-3 2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 1400220-45-2 1-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-(4-chlorophenyl)-urea 
• 1454690-54-0 1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea 
• 1454690-52-8 prop-1-en-2-yl (2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate 
• 1371630-05-5 methyl 8-(3-amino-4-fluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate 
• 1377698-32-2 tert-butyl 5-(5-chloro-2-fluoropyridin-4-yl)-2-fluorophenylcarbamate 
• 1377698-27-5 5-(5-chloro-2-fluoropyridin-4-yl)-2-fluoroaniline 
• 1003575-37-8 2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzenesulfonyl chloride 

Relevant academic research and scientific papers

Para-Selective, Iridium-Catalyzed C-H Borylations of Sulfated Phenols, Benzyl Alcohols, and Anilines Directed by Ion-Pair Electrostatic Interactions

Para C-H borylations (CHB) of tetraalkylammonium sulfates and sulfamates have been achieved using bipyridine-ligated Ir boryl catalysts. Selectivities can be modulated by both the length of the alkyl groups in the tetraalkylammonium cations and the substituents on the bipyridine ligands. Ion pairing, where the alkyl groups of the cation shield the meta C-H bonds in the counteranions, is proposed to account for para selectivity. The 4,4′-dimethoxy-2,2′-bipyridine ligand gave superior selectivities.

The method for producing the phenyl boronic acid ester

PROBLEM TO BE SOLVED: To provide a method for producing phenylboronic acid esters in good yield from diborons and aryl halides by using a nickel catalyst and a base. SOLUTION: In the method for producing phenylboronic acid esters represented by general formula (3), wherein A is an ethylene group or the like which may be substituted by a methyl group, R1is a fluorine atom or the like, and m is an integer of 0-5; diborons and a chlorobenzene derivative are reacted with each other by using a trimethylphosphine coordinated nickel catalyst and alkoxides. COPYRIGHT: (C)2013,JPOandINPIT

RAF INHIBITOR COMPOUNDS

This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.

RAF KINASE INHIBITORS

Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.

NiCl2(PMe3)2-catalyzed borylation of aryl chlorides

The cross-coupling of aryl chlorides and bis(pinacolato)diboron was achieved using NiCl2(PMe3)2 catalyst in the presence of metal 2,2,2-trifluoroethoxide. The catalyst smoothly provided the desired products regardless of a variety of functional groups and substituted positions.

PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS

Compounds of Formula (I) that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula (I), together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, ar