100371-12-8Relevant articles and documents
Novel synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones
Cho, Su-Dong,Song, Sang-Yong,Park, Yong-Dae,Kim, Jeum-Jong,Joo, Woo-Hong,Shiro, Motoo,Falck,Shin, Dong-Soo,Yoon, Yong-Jin
, p. 8995 - 8998 (2007/10/03)
A novel and effective synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones via Smiles rearrangement is presented. Treatment of N-substituted 2-chloro(or hydroxy)acetamide, 2-tetrahydropyranyl-4-chloro-5-hydroxy(or chloro)pyridazin-3-one and cesium carbonate in refluxing acetonitrile was afforded the corresponding pyridazino[4,5-b][1,4]oxazin-3,8-diones in excellent yield.