100379-06-4Relevant academic research and scientific papers
Au(I)-Catalyzed Cyclization/Semipinacol Rearrangement Reaction of Allenes to Construct Quaternary Carbon-Containing Scaffolds
Zheng, Tian-Lu,Zhang, Ye,Gou, A-Long,Cheng, Fu,Liu, Si-Zhan,Yu, Lan,Cui, Ming-Yue,Xu, Xue-Tao,Zhang, Kun,Wang, Shao-Hua
, p. 7073 - 7077 (2020)
The development of methods toward the construction of quaternary carbon centers has been a hot topic in recent years. In this work, an Au(I)-catalyzed intramolecular cyclization/semipinacol rearrangement of allene-containing allylic silyl ether was developed to provide a direct strategy for the construction of multisubstituted cyclohexene-type compounds with a quaternary carbon center in moderate to good yields. In particular, this method provides an alternative synthetic strategy for the construction of a multisubstituted spirocyclo[4.5]decane skeleton and may be applied to the synthesis of related bioactive molecules and their derivatives, thus facilitating the corresponding functional studies.
Reactions of Monosubstituted Acetylenic Alcohols with Allyl Halides
Veliev, M. G.,Shatirova, M. I.,Chalabiev, Ch. A.,Mamedov, I. M.,Mustafaev, A. M.
, p. 52 - 56 (2007/10/03)
Reactions of 2-propynyl alcohol and 2-methyl-3-butyn-2-ol with mono- and dihalogenated propenes yield allylacetylenic alcohols.The kinetic study showed that the reaction rate is governed by both electronic and steric effects of substituents in the allyl halides.
