100379-06-4Relevant articles and documents
Au(I)-Catalyzed Cyclization/Semipinacol Rearrangement Reaction of Allenes to Construct Quaternary Carbon-Containing Scaffolds
Zheng, Tian-Lu,Zhang, Ye,Gou, A-Long,Cheng, Fu,Liu, Si-Zhan,Yu, Lan,Cui, Ming-Yue,Xu, Xue-Tao,Zhang, Kun,Wang, Shao-Hua
, p. 7073 - 7077 (2020)
The development of methods toward the construction of quaternary carbon centers has been a hot topic in recent years. In this work, an Au(I)-catalyzed intramolecular cyclization/semipinacol rearrangement of allene-containing allylic silyl ether was developed to provide a direct strategy for the construction of multisubstituted cyclohexene-type compounds with a quaternary carbon center in moderate to good yields. In particular, this method provides an alternative synthetic strategy for the construction of a multisubstituted spirocyclo[4.5]decane skeleton and may be applied to the synthesis of related bioactive molecules and their derivatives, thus facilitating the corresponding functional studies.
