100379-69-9Relevant articles and documents
Racemic synthesis of 2′-substituted nicotine analogs
Rouchaud, Anne,Kem, William R.
, p. 161 - 166 (2012)
The chemical and pharmacological properties of 2′-substituted nicotines are poorly understood relative to other substituted nicotines. We developed a practical synthesis of the key intermediate (6)-2′- cyanonicotine using the Polonovski reaction. Alkylation of (6)-2′- cyanonicotine with Grignard reagents led to several 2′-alkylnicotines; (6)-2′-aminomethylnicotine, (6)-2′-hydroxymethylnicotine, and (6)-2′- carbamoylnicotine were also synthesized..
