100381-69-9Relevant academic research and scientific papers
A contribution to the synthesis of new cephalosporins: 1-Azacephem
Bizzo, Humberto R.,Antunes,Gemal, Andre L.
, p. 359 - 362 (2003)
The bycyclic β-lactam 1-benzyl-7-phtalimido-4-methyl-6-methylthio-2-oxo-3-cephem was prepared from N-phthaloyl glycine chloride and 1-benzyl-4-methyl-2-methylthio-6-oxo-pyrimidine in 61% yield via a Staudinger reaction.
Highly Regioselective Synthesis of 3,6-Disubstituted 2-(Methylsulfanyl)pyrimidin-4(3 H)-ones
Dos Santos, Josiane M.,Da Silveira, Alessandra S.,Souza, Laura A.,Lobo, Marcio M.,Bonacorso, Helio G.,Martins, Marcos A. P.,Zanatta, Nilo
, p. 3947 - 3955 (2015/12/18)
This study reports a simple and highly regioselective synthesis of a new series of 3,6-disubstituted 2-(methylsulfanyl)pyrimidin-4(3H)-ones, in which the 6-substituents are methyl or aryl groups and the 3-substituents are alkyl, allyl, phenyl, benzyl, or 2-phenylethyl groups. The products are obtained in good yields by cyclocondensation of the appropriate 4-substituted 4-methoxy-1,1,1-trichloroalk-3-en-2-ones with nonsymmetric 1-substituted 2-methylisothiourea sulfates under mild basic conditions.
