1003858-69-2

Basic information

• Product Name: 1H-Indole, 4-fluoro-5-nitro-
• CAS NO: 1003858-69-2
• Mol File: 1003858-69-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 4-fluoro-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 4-fluoro-5-nitro-(1003858-69-2)
• EPA Substance Registry System: 1H-Indole, 4-fluoro-5-nitro-(1003858-69-2)

Safety Data

• Hazardous Substances Data: 1003858-69-2(Hazardous Substances Data)

Usage

General Description

1H-Indole, 4-fluoro-5-nitro- is a chemical compound that belongs to the indole class of organic compounds. It is characterized by the presence of a 4-fluoro-5-nitro- substituent on the 1H-indole molecule. 1H-Indole, 4-fluoro-5-nitro- has potential applications in the pharmaceutical and agrochemical industries due to its diverse biological activities. It has been studied for its anticancer, antimicrobial, and anti-inflammatory properties, and has shown promising results in various preclinical studies. Additionally, it has also been explored for its potential use as a building block in the synthesis of other biologically active molecules. Overall, 1H-Indole, 4-fluoro-5-nitro- is a compound of interest with potential therapeutic and industrial applications.

Upstream product

• 387-43-9 4-fluoroindole 
• 552866-98-5 2,3-dihydro-4-fluoro-1H-indole 
• 860024-83-5 1-(4-fluoroindolin-1-yl)ethanone 
• 1003858-67-0 1-(4-fluoro-5-nitro-2,3-dihydroindol-1-yl)ethanone 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 
• 344790-94-9 1-(2-(2-fluoro-6-nitrophenyl)vinyl)pyrrolidine 
• 1003858-68-1 4-fluoro-5-nitro-2,3-dihydro-1H-indole 

Relevant articles and documents

Synthesis method of 4-fluoro-7-nitroindole or derivatives of 4-fluoro-7-nitroindole

The invention is applicable to the technical field of chemical synthesis, and provides a synthesis method of 4-fluoro-7-nitroindole or derivatives thereof, which comprises the following steps: reacting 4-fluoroindole or derivatives thereof, glacial acetic acid and sodium cyanoborohydride to obtain 4-fluoroindoline or derivatives thereof, reacting the 4-fluoroindoline or derivatives thereof, glacial acetic acid and acetic anhydride to obtain N-acetyl-4-fluoroindoline or a derivative thereof, carrying out nitration reaction on N-acetyl-4-fluoroindoline or a derivative thereof to obtain N-acetyl4-fluoro-7-nitroindoline or a derivative thereof, reacting N-acetyl-4-fluorine 7-nitroindoline or derivatives thereof, sodium hydroxide and 1, 4-dioxane to obtain 4-fluoro-7-nitroindoline or derivatives thereof, and reacting 4-fluoro-7-nitroindoline or derivatives thereof, trichloromethane and manganese dioxide to obtain 4-fluoro-7-nitroindoline or derivatives thereof. The synthesis method provided by the invention is mild in reaction condition and easy to operate.

PYRROLE ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.