1003858-69-2

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole, 4-fluoro-5-nitrois used as a pharmaceutical candidate for its anticancer properties. It has been studied for its ability to inhibit the growth and progression of various types of cancer cells. 1H-Indole, 4-fluoro-5-nitromodulates several oncological signaling pathways, making it a promising agent for cancer treatment.
1H-Indole, 4-fluoro-5-nitrois also used as an antimicrobial agent in the pharmaceutical industry. It demonstrates potential in combating various types of bacteria and other microorganisms, making it a valuable asset in the development of new antimicrobial drugs.
Additionally, 1H-Indole, 4-fluoro-5-nitrois used as an anti-inflammatory agent. Its ability to reduce inflammation and alleviate pain makes it a potential candidate for the treatment of various inflammatory conditions.
Used in Agrochemical Industry:
1H-Indole, 4-fluoro-5-nitrois used as a building block in the synthesis of other biologically active molecules in the agrochemical industry. Its unique structure and properties make it a valuable component in the development of new agrochemicals with improved efficacy and selectivity.

Upstream product

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• 344790-94-9 1-(2-(2-fluoro-6-nitrophenyl)vinyl)pyrrolidine 
• 1003858-67-0 1-(4-fluoro-5-nitro-2,3-dihydroindol-1-yl)ethanone 
• 860024-83-5 1-(4-fluoroindolin-1-yl)ethanone 
• 552866-98-5 2,3-dihydro-4-fluoro-1H-indole 
• 387-43-9 4-fluoroindole 
• 1003858-68-1 4-fluoro-5-nitro-2,3-dihydro-1H-indole 

Relevant academic research and scientific papers

Synthesis method of 4-fluoro-7-nitroindole or derivatives of 4-fluoro-7-nitroindole

The invention is applicable to the technical field of chemical synthesis, and provides a synthesis method of 4-fluoro-7-nitroindole or derivatives thereof, which comprises the following steps: reacting 4-fluoroindole or derivatives thereof, glacial acetic acid and sodium cyanoborohydride to obtain 4-fluoroindoline or derivatives thereof, reacting the 4-fluoroindoline or derivatives thereof, glacial acetic acid and acetic anhydride to obtain N-acetyl-4-fluoroindoline or a derivative thereof, carrying out nitration reaction on N-acetyl-4-fluoroindoline or a derivative thereof to obtain N-acetyl4-fluoro-7-nitroindoline or a derivative thereof, reacting N-acetyl-4-fluorine 7-nitroindoline or derivatives thereof, sodium hydroxide and 1, 4-dioxane to obtain 4-fluoro-7-nitroindoline or derivatives thereof, and reacting 4-fluoro-7-nitroindoline or derivatives thereof, trichloromethane and manganese dioxide to obtain 4-fluoro-7-nitroindoline or derivatives thereof. The synthesis method provided by the invention is mild in reaction condition and easy to operate.

5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES

The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, the treatment of HIV, autoimmune diseases, infections, atherosclerosis, and ischemia–reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

PYRROLE ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.