860024-83-5

Basic information

• Product Name: 1-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-Ethanone
• Synonyms: 1-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-Ethanone;1-Acetyl-2,3-dihydro-4-fluoro-1H-indole, 1-(2,3-Dihydro-4-fluoro-1H-indol-1-yl)ethan-1-one;1-Acetyl-4-fluoroindoline
• CAS NO: 860024-83-5
• Molecular Formula: C10H10FNO
• Molecular Weight: 179.1909032
• Mol File: 860024-83-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-Ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-Ethanone(860024-83-5)
• EPA Substance Registry System: 1-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-Ethanone(860024-83-5)

Safety Data

• Hazardous Substances Data: 860024-83-5(Hazardous Substances Data)

Usage

Structure

1-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-Ethanone

Type of compound

Chemical compound

Derivative of

Indole

Indole

Heterocyclic compound found in natural products and pharmaceuticals

4-fluoro substituent

Makes the compound a useful building block for biologically active compounds

Ethanone group

At the 1-position, adds versatility for further modification and functionalization

Potential uses

Pharmaceutical applications

Role in synthesis

Valuable intermediate in organic synthesis

Upstream product

• 75-36-5 acetyl chloride 
• 552866-98-5 2,3-dihydro-4-fluoro-1H-indole 
• 108-24-7 acetic anhydride 
• 387-43-9 4-fluoroindole 
• 344790-94-9 1-(2-(2-fluoro-6-nitrophenyl)vinyl)pyrrolidine 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 

Downstream Products

• 1003858-69-2 4-fluoro-5-nitro-1H-indole 
• 1003858-66-9 4-fluoro-1H-indol-5-amine 
• 1167056-95-2 4-fluoro-7-nitro-1H-indole 

Relevant articles and documents

Synthesis method of 4-fluoro-7-nitroindole or derivatives of 4-fluoro-7-nitroindole

The invention is applicable to the technical field of chemical synthesis, and provides a synthesis method of 4-fluoro-7-nitroindole or derivatives thereof, which comprises the following steps: reacting 4-fluoroindole or derivatives thereof, glacial acetic acid and sodium cyanoborohydride to obtain 4-fluoroindoline or derivatives thereof, reacting the 4-fluoroindoline or derivatives thereof, glacial acetic acid and acetic anhydride to obtain N-acetyl-4-fluoroindoline or a derivative thereof, carrying out nitration reaction on N-acetyl-4-fluoroindoline or a derivative thereof to obtain N-acetyl4-fluoro-7-nitroindoline or a derivative thereof, reacting N-acetyl-4-fluorine 7-nitroindoline or derivatives thereof, sodium hydroxide and 1, 4-dioxane to obtain 4-fluoro-7-nitroindoline or derivatives thereof, and reacting 4-fluoro-7-nitroindoline or derivatives thereof, trichloromethane and manganese dioxide to obtain 4-fluoro-7-nitroindoline or derivatives thereof. The synthesis method provided by the invention is mild in reaction condition and easy to operate.

PYRROLE ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.