1003890-41-2

Upstream product

• 1003890-38-7 C₂₈H₄₅O₇PSi 
• 887343-98-8 (4R,6R)-2-Allyloxy-4,6-divinyl-[1,3,2]dioxaphosphinane 2-oxide 
• 1003890-33-2 C₂₂H₃₈O₃Si 
• 887143-81-9 (1S,6R,8R)-8-Vinyl-2,9,10-trioxa-1-phospha-bicyclo[4.3.1]dec-4-ene 1-oxide 

Downstream Products

• 1003890-43-4 C₂₉H₅₁O₇PSi 
• 1003890-58-1 (4S,6S,9R,10S,11R)-12-(tert-butyldimethylsilyloxy)-10-(4-methoxybenzyloxy)-9,11-dimethyldodec-1-ene-4,6-diol 
• 1003890-45-6 ((2R,3S,4R)-6-((4S,6S)-6-allyl-2,2-dimethyl-1,3-dioxan-4-yl)-3-(4-methoxybenzyloxy)-2,4-dimethylhexyloxy)(tert-butyl)dimethylsilane 
• 1003890-60-5 C₃₀H₅₂O₆Si 
• 1003890-47-8 C₃₅H₆₂O₆Si 
• 1003890-62-7 1-((4R,6S)-6-((3R,4S,5R)-6-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,5-dimethylhexyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-methylhex-5-en-2-one 
• 1003890-49-0 C₃₂H₅₆O₆Si 
• 1003890-51-4 (5S,7R,9S,12R,13S,14R)-15-(tert-butyldimethylsilyloxy)-13-(4-methoxybenzyloxy)-2,12,14-trimethylpentadec-1-ene-5,7,9-triol 
• 1303438-67-6 (5S,7R,9S,12R,13S,14R)-15-hydroxy-13-(4-methoxybenzyloxy)-2,12,14-trimethylpentadec-1-ene-5,7,9-triyl triacetate 
• 1303438-60-9 (2S,3S,4R,7S,9R,11S)-7,9,11-triacetoxy-3-(4-methoxybenzyloxy)-2,4,14-trimethylpentadec-14-enoic acid 
• 1303438-68-7 (5S,7R,9S,12R,13S,14S)-15-((2S,3R,7R,E)-2-((4S,6R)-2,2-dimethyl-6-(pent-4-enyl)-1,3-dioxan-4-yl)-5-methyl-7-(triethylsilyloxy)dec-4-en-3-yloxy)-13-(4-methoxybenzyloxy)-2,12,14-trimethyl-15-oxopentadec-1-ene-5,7,9-triyl triacetate 
• 1303438-79-0 (5S,7R,9S,12R,13S,14S)-15-((2S,3R,7R,E)-2-((4S,6R)-2,2-dimethyl-6-(pent-4-enyl)-1,3-dioxan-4-yl)-7-hydroxy-5-methyldec-4-en-3-yloxy)-13-(4-methoxybenzyloxy)-2,12,14-trimethyl-15-oxopentadec-1-ene-5,7,9-triyl triacetate 
• 1303438-69-8 (5S,7R,9S,12R,13S,14S)-15-((2S,3R,7R,E)-7-acetoxy-2-((4S,6R)-2,2-dimethyl-6-(pent-4-enyl)-1,3-dioxan-4-yl)-5-methyldec-4-en-3-yloxy)-13-(4-methoxybenzyloxy)-2,12,14-trimethyl-15-oxopentadec-1-ene-5,7,9-triyl triacetate 
• 1303438-80-3 (5S,7R,9S,12R,13S,14S)-15-((4R,8R,9S,10S,12R,E)-4-acetoxy-10,12-dihydroxy-6,9-dimethylheptadeca-6,16-dien-8-yloxy)-13-(4-methoxybenzyloxy)-2,12,14-trimethyl-15-oxopentadec-1-ene-5,7,9-triyl triacetate 

Relevant academic research and scientific papers

A phosphate tether-mediated, one-pot, sequential ring-closing metathesis/cross-metathesis/chemoselective hydrogenation protocol

A versatile three-step, one-pot, sequential reaction protocol involving ring-closing metathesis, cross-metathesis, and chemoselective hydrogenation is reported. This phosphate tether-mediated process occurs without intermediate isolation, is chemoselectiv

Total synthesis of dolabelide C: A phosphate-mediated approach

The first synthesis of dolabelide C (1), a cytotoxic marine macrolide, is reported utilizing a phosphate tether-mediated approach. Bicyclic phosphates (S,S,SP)-5 and (R,R,RP)-5 serve as the central building blocks for the constructio

A multifaceted phosphate tether: Application to the C1-C14 subunit of dolabelides A-D

A phosphate tether approach to the C1-14 subunit of dolabelide is described. The phosphate tether serves a multifaceted role mediating several processes, including (i) diastereotopic differentiation via RCM, (ii) selective CM by imparting Type III behavior to the exocyclic olefin, (iii) regioselective hydrogenation, and (iv) regioselective Pd(0)-catalyzed reductive opening of the bicyclic phosphate. Overall, this strategy uses orthogonal protecting- and leaving-group properties innate to phosphate esters to rapidly assembly the titled subunit.