100390-48-5

Basic information

• Product Name: PHENYL-PYRROLIDIN-1-YL-ACETIC ACID
• Synonyms: TIMTEC-BB SBB011111;PHENYL-PYRROLIDIN-1-YL-ACETIC ACID;Phenyl-pyrrolidin-1-yl-acetyl acid;α-Phenyl-1-pyrrolidineacetic Acid;alpha-Phenyl-1-pyrrolidineacetic acid;a-Phenyl-1-pyrrolidineacetic acid HCl;1-Pyrrolidineaceticacid, a-phenyl-
• CAS NO: 100390-48-5
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.25
• Product Categories: Aromatics;Heterocycles
• Mol File: 100390-48-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PHENYL-PYRROLIDIN-1-YL-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL-PYRROLIDIN-1-YL-ACETIC ACID(100390-48-5)
• EPA Substance Registry System: PHENYL-PYRROLIDIN-1-YL-ACETIC ACID(100390-48-5)

Safety Data

• Hazardous Substances Data: 100390-48-5(Hazardous Substances Data)

Usage

Uses

A N-pyrrolyl derivative acid which possess analgesic and plaque antiaggregating properties.

Upstream product

• 123-75-1 pyrrolidine 
• 298-12-4 Glyoxilic acid 
• 98-80-6 phenylboronic acid 

Downstream Products

• 100609-39-0 methyl 2-phenyl-2-(pyrrolidin-1-yl)acetate 

Relevant articles and documents

Diastereoselective Petasis Mannich reactions accelerated by hexafluoroisopropanol: A pyrrolidine-derived arylglycine synthesis

A diastereoselective synthesis of pyrrolidine-derived arylglycines has been developed using the Petasis boronic acid Mannich reaction. High diastereoselectivities in the reactions of chiral amines, aryl boronic acids, and glyoxylic acid monohydrate have been demonstrated for the first time. Key to the implementation of this method is the discovery that hexafluoroisopropanol accelerates the Petasis process, reducing reaction times from multiple days to less than 24 h.