1003924-50-2Relevant articles and documents
Enantioselective synthesis of chiral sulfones by Rh-catalyzed asymmetric addition of boronic acids to α,β-unsaturated 2-pyridyl sulfones
Mauleon, Pablo,Alonso, Ines,Rivero, Marta Rodriguez,Carretero, Juan C.
, p. 9924 - 9935 (2007)
(Chemical Equation Presented) A general and efficient method for the rhodium-catalyzed enantioselective catalytic conjugate addition of organoboronic acids to α,β-unsaturated sulfones is described. The success of the process relies on the use of α,β-unsat
ISOTHIOCYANATE COMPOUND AND APPLICATION THEREOF
-
Paragraph 0086; 0087, (2018/02/28)
The present invention provides an isothiocyanate compound and its application. The compound is an aryl-substituted isothiocyanate compound that has a structure of the general formula I. The isothiocyanate compound of the present invention has very good solubility in water, far better inhibitory activity for XPO1 protein than other non-aryl substituted congeneric compounds, little side effects, and good biological safety and bioavailability, and is quite suitable for clinical application. Therefore, the isothiocyanate compound would have tremendous potential market space and economic benefits.
Thermolyses of α-phosphorylmethyl tetrazolyl sulfoxides in the presence of 2,3-dimethyl-1,3-butadiene and their reactions with several amines
Morita, Hiroyuki,Tashiro, Shintaro,Takeda, Masahiro,Fujimori, Ken,Yamada, Nobuhiko,Chanmiya Sheikh,Kawaguchi, Hiroyuki
, p. 3589 - 3595 (2008/09/20)
We have synthesized α-(phosphoryl)methyl tetrazolyl sulfoxides and examined the reactivities in the thermolyses and in the presence of several amines, such as aniline, benzylamine, piperidine, pyrrolidine, and morpholine. Thermolyses of the derivatives in the presence of 2,3-dimethyl-1,3-butadiene afforded 2-phosphoryl substituted 4,5-dimethyl-3,6-dihydro-2H-thiopyran S-oxide. In addition, novel phosphinecarbothioamides were obtained in the reaction of the derivatives with amines.