1021879-82-2

Basic information

• Product Name: α-(diethoxyphosphoryl)methyl 5-(1-phenyl)-1H-tetrazolyl sulfoxide
• Synonyms: α-(diethoxyphosphoryl)methyl 5-(1-phenyl)-1H-tetrazolyl sulfoxide
• CAS NO: 1021879-82-2
• Molecular Weight: 344.331
• Mol File: 1021879-82-2.mol

Chemical Properties

• CAS DataBase Reference: α-(diethoxyphosphoryl)methyl 5-(1-phenyl)-1H-tetrazolyl sulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: α-(diethoxyphosphoryl)methyl 5-(1-phenyl)-1H-tetrazolyl sulfoxide(1021879-82-2)
• EPA Substance Registry System: α-(diethoxyphosphoryl)methyl 5-(1-phenyl)-1H-tetrazolyl sulfoxide(1021879-82-2)

Safety Data

• Hazardous Substances Data: 1021879-82-2(Hazardous Substances Data)

Upstream product

• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 1003924-50-2 α-(diethoxyphosphoryl)methyl 5-(1-phenyl)-1H-tetrazolyl sulfide 
• 31618-90-3 diethyl (p-toluenesulfonyloxymethane)phosphonate 

Downstream Products

• 5378-52-9 phenyl-1H-tetrazole 
• 1021879-92-4 diethoxyphosphorylthioformic acid pyrrolidide 
• 1021879-91-3 diethoxyphosphorylthioformic acid piperidide 
• 1021879-87-7 3,4-dimethyl-6-(diethoxyphosphoryl)-2H-thiopyran 
• 1021879-86-6 4,5-dimethyl-2-(diethoxyphosphoryl)-3,6-dihydro-2H-thiopyran S-oxide 
• 110461-12-6 diethyl phenylaminothiocarbonylphosphonate 
• 81940-06-9 diethoxyphosphorylthioformic acid benzylamide 

Relevant articles and documents

ISOTHIOCYANATE COMPOUND AND APPLICATION THEREOF

The present invention provides an isothiocyanate compound and its application. The compound is an aryl-substituted isothiocyanate compound that has a structure of the general formula I. The isothiocyanate compound of the present invention has very good solubility in water, far better inhibitory activity for XPO1 protein than other non-aryl substituted congeneric compounds, little side effects, and good biological safety and bioavailability, and is quite suitable for clinical application. Therefore, the isothiocyanate compound would have tremendous potential market space and economic benefits.

Thermolyses of α-phosphorylmethyl tetrazolyl sulfoxides in the presence of 2,3-dimethyl-1,3-butadiene and their reactions with several amines

We have synthesized α-(phosphoryl)methyl tetrazolyl sulfoxides and examined the reactivities in the thermolyses and in the presence of several amines, such as aniline, benzylamine, piperidine, pyrrolidine, and morpholine. Thermolyses of the derivatives in the presence of 2,3-dimethyl-1,3-butadiene afforded 2-phosphoryl substituted 4,5-dimethyl-3,6-dihydro-2H-thiopyran S-oxide. In addition, novel phosphinecarbothioamides were obtained in the reaction of the derivatives with amines.