100396-73-4

Upstream product

• 95-48-7 ortho-cresol 
• 618-41-7 Benzenesulfinic acid 
• 80-17-1 benzenesufonyl hydrazide 
• 14204-24-1 N-(phenylthio)succinimide 
• 882-33-7 diphenyldisulfane 
• 67-66-3 chloroform 
• 7577-74-4 6-acetoxy-6-methylcyclohexa-2,4-dienone 
• 108-98-5 thiophenol 
• 121-44-8 triethylamine 

Downstream Products

• 107777-42-4 5-benzenesulfonyl-2-methoxy-toluene 
• 100396-92-7 2-methyl-4-(phenylsulfinyl)phenol 
• 105901-77-7 4-benzenesulfonyl-2-methyl-phenol 
• 107777-12-8 1-methoxy-2-methyl-4-(phenylsulfanyl)benzene 

Relevant academic research and scientific papers

Regioselective thiolation of electron rich arenes and heterocycles in recyclable catalytic media

A convenient and novel approach has been developed for the synthesis of unsymmetrical diaryl sulfides by the reaction of sulfonyl hydrazides with phenols using a [Bmim][Br] ionic liquid through the formation of C-S bonds. The reaction has further been extended to indole, β-naphthol and aromatic amine moieties. This protocol offers a new, versatile and greener approach for thiolation of natural phenols (monoterpenes)/aromatic phenols/β-naphthols/aromatic amines and indoles without using any catalyst. A broad range of functional groups were well tolerated in this reaction system.

Iron or boron-catalyzed C-H arylthiation of substituted phenols at room temperature

A simple, efficient and environmentally friendly method for iron or boron-catalyzed C-H arylthiation of substituted phenols at room temperature has been developed, and the corresponding diaryl sulfides were prepared in good to excellent yields. The protocol uses readily available 1-(substituted phenylthio)pyrrolidine-2,5-diones as the arylthiation reagents and inexpensive and environmentally friendly FeCl3 or BF3·OEt 2 as the catalyst, moreover no ligands, additives or extrusion of air are required, and the reactions can be performed successfully at room temperature. This journal is the Partner Organisations 2014.

FeCl3-mediated direct chalcogenation of phenols

Direct sulfenylation and selenylation of phenols using a stoichiometric amount of FeCl3 under an oxygen atmosphere has been developed. The chalcogenated phenols were shown to be suitable for preparing S- and Se-containing compounds using the reaction of the remaining hydroxy group.

Mercapto phenolic and alkylthio phenolic antioxidants

2-Mercapto phenol and/or 4-mercapto phenol are reacted with a compound selected from olefins, alcohols, and organic halides for example, styrene and isobutylene, to form (hydrocarbyl) thio phenolic antioxidants such as 2,6-di-tert. butyl-4-(tert.butylthio) phenol and 2,6-di(α-phenylethyl)-4-(α-phenylethylthio)phenol.