1004-52-0Relevant academic research and scientific papers
Direct asymmetric α-hydroxylation of β-hydroxyketones
Lopp, Margus,Paju, Anne,Kanger, Tonis,Pehk, Tonis
, p. 5051 - 5054 (1997)
Direct oxidation of racemic β-hydroxyketones 1a-c under Sharpless oxidation conditions resulted in the enantiomeric α,β-dihydroxyketones 2a in 97% ee, 2b in 86% ee and 2c in 95% ee respectively, in 37-58% of isolated yield. The oxidation is assumed to pro
Direct asymmetric α-hydroxylation of 2-hydroxymethyl ketones
Paju, Anne,Kanger, T?nis,Pehk, T?nis,Lopp, Margus
, p. 7321 - 7326 (2002)
A direct α-hydroxylation of racemic 2-hydroxymethyl ketones with the Sharpless epoxidation catalyst resulted in α,β-dihydroxy ketones in high ee (up to 97%) and in moderate to good isolated yield (up to 58%).
Fragmentation of bicyclic γ-silyloxy-β-hydroxy-α- diazolactones as an approach to ynolides
Bayir, Ali,Brewer, Matthias
, p. 6037 - 6046 (2014/07/21)
Medium-sized ynolides were prepared by the Lewis acid-mediated fragmentation of bicyclic γ-silyloxy-β-hydroxy-α-diazolactones in which the Cβ-Cγ bond is the ring fusion bond. Although these lactone fragmentation substrates reacted somewhat less efficientl
Synthesis of 3-Hydroxy-3-(hydroxymethyl)-5-methylcyclohexane-1,2-dione Dibenzoate, a Reported Hydrolytic Degradation Product of Leucogenenol
Aberhart, D. John,Clardy, Jon,Ghoshal, Pallab K.,He, Cun-heng,Zheng, Qi-tai
, p. 2429 - 2433 (2007/10/02)
2-Hydroxy-2-(hydroxymethyl)cyclohexanone (3a), 2-hydroxy-2-(hydroxymethyl)-4-methylcyclohexanone (3b), and 2-hydroxy-2-(hydroxymethyl)-5-methylcyclohexanone (6) were converted with MoO5*pyridine*HMPA (MoOPH) into the respective 6-hydroxy analogues, which
