127944-74-5Relevant academic research and scientific papers
Antibiotics from Gliding Bacteria, XLII. Chemical Modification of Sorangicin A and Structure - Activity Relationship I: Carboxyl and Hydroxyl Group Derivatives
Jansen, Rolf,Schummer, Dietmar,Irschik, Herbert,Hoefle, Gerhard
, p. 975 - 988 (2007/10/02)
The synthesis of selectively protected sorangicin A derivatives and their application in the modification of the hydroxyl groups and the carboxyl group in sorangicin A (1) is described.Esters, amides, and sorangicins modified at the hydroxyl groups were prepared and their activities against Staphylococcus aureus, Escherichia coli, and their in vitro inhibition of RNA polymerase were examined.Although no sorangicin A derivatives with superior biological activity were observed, some derivatives completely retained their antibiotic activity or were slightly improved in their activity with certain strains.
