100422-86-4Relevant articles and documents
Nucleophilic Aminomethylation of Aldehydes with α-Amino Alkylsilanes
Tsuge, Otohiko,Tanaka, Junji,Kanemasa, Shuji
, p. 1991 - 1999 (2007/10/02)
Fluoride-induced desilylation of (α-phthalimido-, α-morpholino-, and α-acetamidobenzyl)silanes and a (phthalimidomethyl)silane generates the corresponding α-amino carbanions which add to a variety of aldehydes.The conversion of phthalimido group of the adducts into amino moiety leads to β-amino alcohols.This simple reaction sequence offers a new and general method of nucleophilic aminomethylation.