1004282-76-1

Basic information

• Product Name: 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine
• Synonyms: 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine
• CAS NO: 1004282-76-1
• Molecular Formula: C₁₁H₁₄F₃N
• Molecular Weight: 217.2307696
• Product Categories: Aminomethyl's;Phenyls & Phenyl-Het
• Mol File: 1004282-76-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine(1004282-76-1)
• EPA Substance Registry System: 2-Methyl-2-[4-(trifluoromethyl)phenyl]propan-1-amine(1004282-76-1)

Safety Data

• Hazardous Substances Data: 1004282-76-1(Hazardous Substances Data)

Upstream product

• 32445-87-7 2-methyl-2-(4-(trifluoromethyl)phenyl)propanenitrile 

Downstream Products

• 1365760-26-4 [2-methyl-2-(4-trifluoromethyl-phenyl)-propyl]-carbamic acid ethyl ester 

Relevant articles and documents

Synthesis of indolines by copper-mediated intramolecular aromatic C-H amination

A Cu(OAc)2-mediated intramolecular aromatic C-H amination proceeds with the aid of a picolinamide-type bidentate coordination group to deliver the corresponding indolines in good yields. The reaction occurs smoothly even under noble-metal-free conditions, and in some cases the use of an MnO2 terminal oxidant renders the process catalytic in Cu. The mild oxidation aptitude of Cu(OAc)2 and/or MnO2 accommodates the formation of electron-rich thiophene-and indole-fused indoline analogues. The Cu-based system can provide an effective approach to various indolines of potent interest in pharmaceutical and medicinal chemistry.

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.