100429-08-1

Upstream product

• 1052689-06-1 8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-((lR)-2-(p-methoxy phenyl)-1-methylethyl) amino] ethyl} carbostyril hydrochloride 
• 108-20-3 di-isopropyl ether 
• 148-24-3 8-quinolinol 
• 100331-89-3 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one 
• 2598-31-4 5-acetyl-8-hydroxyquinoline 
• 26872-48-0 1-(8-benzyloxyquinolin-5-yl)ethanone 
• 100331-93-9 5-Acetyl-8-benzyloxyquinoline-N-oxide 
• 57434-96-5 5-acetyl-8-hydroxyquinoline hydrochloride 
• 100429-06-9 8-benzyloxy-5-{(1S)-1-hydroxy-2-[N-((1S)-2-(p-methoxyphenyl)-1-methylethyl)amino]ethyl}carbostyril 

Relevant academic research and scientific papers

PROCESS FOR PREPARING ISOMERS OF CARMOTEROL

A process for preparing a compound of formula (III) comprising condensing an oxiranyl compound of formula (I) with an amine of formula (II) or a salt thereof wherein: R1 is a group selected from alkyl, aryl, allyl, alkoxy, cycloalkyl, heterocyclic, alkenyl, benzocycloalkyl, aralkyl, haloarylalkyl, heteroaralkyl, haloalkyl, alkoxyaralkyl, substituted silyl and benzyl; and R2 is hydrogen, optionally substituted silyl or optionally substituted benzyl. Formula (I), (II) and (III): There is also described a process for preparing (R,R)-carmoterol from compound (III).

Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride

The invention relates to a process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2 [[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride of formula (I). Useful intermediates in the process are also disclosed.

8-HYDROXY-5-[(-HYDROXY-2-[[ (1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL] AMINO ][ETHYL] -2(1H)-QUINOLINONE MONOHYDROCHLORIDE IN CRYSTALLINE FORM AND THE PROCESS FOR ITS PREPARATION

The invention relates to 8-hydroxy-5- [(1 R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methyl ethyl] amino] ethyl] -2 (1 H)-quinolinone monohydrochloride of formula (I) in crystalline form, provided with suitable characteristics in order to be used for the

Bronchodilating 8-hydroxy-5-{(1R)-1-hydroxy-2-[N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)-amino]ethyl} carbostyril

A novel carbostyril derivative of the formula: STR1 or a pharmaceutically acceptable acid addition salt thereof, and a process for preparing same. The compound (I) shows potent bronchodilating activity and is useful as a bronchodilator.