17341-93-4

Basic information

• Product Name: 2,2,2-Trichloroethyl chloroformate
• Synonyms: BETA,BETA,BETA-TRICHLOROETHOXYCARBONYL CHLORIDE;CHLOROFORMIC ACID 2,2,2-TRICHLOROETHYL ESTER;2,2,2-TRICHLOROETHYL CHLOROFORMATE;2,2,2-TRICHLORO-ETHOXYCARBONYL CHLORIDE;2,2,2-Trichloroethyl chloridocarbonate;carbonochloridicacid,2,2,2-trichloroethylester;Formic acid, chloro-, 2,2,2-trichloroethyl ester;Trichloroethyl chloroformate
• CAS NO: 17341-93-4
• Molecular Formula: C₃H₂Cl₄O₂
• Molecular Weight: 211.86
• EINECS: 241-363-7
• Product Categories: CHLOROFORMATES;Miscellaneous;Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry;Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 17341-93-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 1°C
• Boiling Point: 171-172 °C(lit.)
• Flash Point: >100°C
• Appearance: Clear light yellow/Liquid
• Density: 1.539 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.06 psi ( 20 °C)
• Refractive Index: n20/D 1.471(lit.)
• Storage Temp.: 2-8°C
• Water Solubility: Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water.
• Sensitive: Moisture Sensitive
• BRN: 970619
• CAS DataBase Reference: 2,2,2-Trichloroethyl chloroformate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trichloroethyl chloroformate(17341-93-4)
• EPA Substance Registry System: 2,2,2-Trichloroethyl chloroformate(17341-93-4)

Safety Data

• Hazard Codes: T
• Statements: 23-34-36
• Safety Statements: 26-36/37/39-45-7/9
• RIDADR: UN 3277 6.1/PG 2
• WGK Germany: 3
• F: 10-19
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 17341-93-4(Hazardous Substances Data)

Usage

Chemical Properties

Clear light yellow liquid

Uses

Different sources of media describe the Uses of 17341-93-4 differently. You can refer to the following data:
1. 2,2,2-Trichloroethyl chloroformate is used as a protecting reagent for aliphatic and aromatic hydroxyl and amino groups. It is used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples, during N-demethylation of dextromethorphan. It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.
2. 2,2,2-Trichloroethyl chloroformate was used as:derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samplesstarting reagent during the synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester (IV)reagent during N-demethylation of dextromethorphanprotecting group reagent for amines and alcohols

InChI:InChI=1/C3H2Cl4O2/c4-2(8)9-1-3(5,6)7/h1H2

Upstream product

• 75-44-5 phosgene 
• 115-20-8 1,1,1-trichloroethanol 
• 71674-20-9 Thiocarbonic acid S-ethyl ester O-(2,2,2-trichloro-ethyl) ester 

Downstream Products

• 71424-98-1 (S)-2-Benzyloxycarbonyl-4-benzyloxycarbonylamino-pentanedioic acid dibenzyl ester 
• 71389-38-3 (S)-2-Benzyloxycarbonylamino-4-methoxycarbonyl-pentanedioic acid 1-benzyl ester 5-methyl ester 
• 19394-12-8 4-nitrophenyl 2,2,2-trichloroethyl carbonate 
• 37888-21-4 2,2,2-Trichloroethyloxycarbonyl-L-Phenylalanine 
• 59577-43-4 2-(2,2,2-Trichloraethoxycarbonyloxyimino)-2-phenyl-acetonitril 
• 57487-30-6 C₁₈H₁₄Cl₅N₅O₂ 
• 37888-25-8 O-benzyl-N-Tcc-L-tyrosine 
• 26553-34-4 N-trichloroethoxycarbonyl-D-phenylglycine 
• 67354-46-5 N-(2,2,2-Trichlorethoxycarbonyl)-aminomalonsaeuredibenzylester 
• 61566-80-1 (S)-phenyl-(2,2,2-trichloro-ethoxycarbonyloxy)-acetic acid benzyl ester 
• 37469-81-1 7c-methyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 39741-93-0 (6R)-3-methyl-7-(4-nitro-benzylideneamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2,7c-dicarboxylic acid bis-(2,2,2-trichloro-ethyl) ester 
• 90601-56-2 2-(β-N-2,2,2-Trichloroethoxycarbonyl-N-methyl-aminoethyl)-4,5,3',4'-tetramethoxystilbene 
• 28126-22-9 2,2,2-trichloroethyl methylcarbamate 

Relevant articles and documents

Piperidine derivatives having renin inhibiting activity

Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I wherein R1, R2, R3, R4, Q, X, Z, m and n are as described herein.

Protection of functional groups during reaction and their subsequent restoration

In the process for preparing an organic compound of the formula in which X is an amino group, a hydroxyl group or a carboxyl group, and A' is the remainder of the molecule, from an organic compound of the formula in which A is the remainder of the molecule which can undergo reaction to form A', by converting A -- X into a compound of the formula in which Z is --NH--, --O-- or a direct C--C bond, and R is a radical of the formula STR1 IN WHICH Y is a direct C--C single bond, the --CH=CH-- group or an arylene group, R1 to R4 each independently is hydrogen, halogen or an alkyl, aryl, aralkyl, alkoxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl or cycloalkylaminocarbonyl radical, or R1 + r2 and R3 + R4 each independently completes a 5- or 6-membered carbocyclic ring, or R1 and R3 conjointly with the grouping --C--Y--C-- forms a carbocyclic ring with 5 or 6 carbon atoms, and Hal is halogen, Thereby to protect X, then converting A -- Z -- COOR into a compound of the formula and then treating the compound A' -- Z -- COOR to restore the group X, the improvement which comprises effecting the treatment of the compound A' -- Z -- COOR with an alkali metal compound of a complex of monovalent cobalt. The process is applicable particularly to aminocarboxylic acids including intermediates from various stages of the synthesis of penicillins and cephalosporins.