10045-68-8

Usage

Uses

Used in Pharmaceutical Research:
4-Acetyl-2-phenylimidazole is used as a starting material for the production of various pharmaceuticals and other organic compounds. Its unique chemical structure and properties make it a valuable component in the synthesis of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Acetyl-2-phenylimidazole is employed as a key intermediate in the preparation of a wide range of organic compounds. Its reactivity and functional groups allow for the formation of various chemical bonds and reactions, facilitating the synthesis of complex molecules.
Used in Anticancer Applications:
4-Acetyl-2-phenylimidazole is used as an anticancer agent, exhibiting potential anti-tumor activity. Its bioactivity has been studied for its ability to target and inhibit the growth of cancer cells, making it a promising candidate for the development of novel cancer therapies.
Used in Anti-inflammatory Applications:
In addition to its anti-cancer properties, 4-Acetyl-2-phenylimidazole has also been studied for its anti-inflammatory effects. It may be used as an anti-inflammatory agent to alleviate inflammation and reduce the associated symptoms in various medical conditions.

Upstream product

• 103747-71-3 N-(5-methyl-4-isoxazolyl)benzamide 
• 1670-14-0 benzamidine monohydrochloride 
• 91157-98-1 2-chloro-1,1-dimethoxybutan-3-one 
• 97602-49-8 (E)-4-(5-Phenyl-tetrazol-1-yl)-but-3-en-2-one 
• 98-88-4 benzoyl chloride 
• 99280-78-1 (1-methyl-2-phenyl-1H-imidazol-4-yl)methanol 
• 10045-54-2 α-Methyl-2-phenyl-4-imidazolemethanol 
• 618-39-3 benzamidin 

Downstream Products

• 647031-06-9 1-(1-methoxymethyl-2-phenyl-1H-imidazol-4-yl)ethanone 
• 1258215-26-7 4-acetyl-1-isopropyl-2-phenylimidazole 
• 68283-26-1 3-[1-(2-phenyl-4-imidazolyl)ethylidene]carbazic acid, methyl ester 

Relevant academic research and scientific papers

Concise, flexible syntheses of 4-(4-imidazolyl)pyrimidine cyclin-dependent kinase 2 (CDK2) inhibitors

A flexible six-step synthesis of potential cyclin-dependent kinase 2 (CDK2) inhibitors is reported. The synthesis involves the condensation between 3-chloro-4,4-dimethoxy-2-butanone and amidines, which provides acetyl-imidazoles and late stage palladium-catalyzed N-arylation to give the target pyrimidine derivatives.

IMIDAZOLES, OXAZOLES AND THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITIES

The present invention provides compounds of formula I: (I) or a pharmaceutically acceptable derivative thereof, wherein R1, R2, A, G, and W are as described in the specification. These compounds are inhibitors of protein kinase, part

Synthesis of 4(5)-Acyl-, 1-Substituted 5-Acyl, and 1-Substituted 4-Acyl-1H-imidazoles from 4-Aminoisoxazoles

4-Aminoisoxazoles can be acylated with a wide variety of activated carboxylic acids.Hydrogenation of the resulting amides gives α-(acylamino)enaminones, which cyclize to 4(5)-acylimidazoles upon treatment with base.This method allows for the synthesis of acylimidazoles with a wide range of substituents at C-2.Utilization of N-substituted 4-aminoisoxazoles in the same sequence of reactions yields 1-substituted 5-acylimidazoles, a substitution pattern not otherwise easily prepared.Treatment of α-(acylamino)enaminones, derived from N-unsubstituted isoxazoles, with primary amines leads to incorporation of the amine at the β-position with concomitant expulsion of ammonia.This sequence efficiently yields 1-substituted and 1,2-disubstituted 4-acylimidazoles but does not give satisfactory yields of 5-substituted 4-acylimidazoles due to steric inhibition of the amine exchange.

Two-step Synthesis of Imidazoles from Activated Alkynes

Conjugate addition of 2-(tri-n-butylstannyl)tetrazoles (1) to activated alkynes gives 1-alkenyltetrazoles (4) and (5) predominantly.Use of the N-tributylstannyl derivatives, rather than the parent tetrazole, gives a high ratio of 1- to 2-alkenyl isomers and avoids the complication of further addition of the tetrazole or the alkyne to the initial adduct.Irradiation of the (Z)- and (E)-1-alkenyltetrazoles (4) and (5) at 254 nm then gives the expected imidazoles in moderate yield.However, 5-phenyl-2-(tri-n-butylstannyl)tetrazole (1a) reacted only slowly with ethyl phenylpropiolate to give ethyl 3,5-diphenylpyrazole-4-carboxylate (8), presumably via the 2-alkenyltetrazole (9) formed in preference to the 1-isomer for steric reasons.

A GENERAL SYNTHESIS OF 4(5)-ACYLIMIDAZOLES FROM 4-ACYLAMINOISOXAZOLES.

2-Substituted-4(5)-acyl, 1,2-disubstituted 4-acyl and 1,2-disubstituted-5-acylimidazoles can be specifically prepared from 4-aminoisoxazoles.

Synthesis of 2-Substituted 5-Acetyl-1(H)-imidazoles via 3-Chloro-4,4-dimethoxy-2-butanone and Related 3,4-Disubstituted 3-Buten-2-ones

A variety of 3,4-disubstituted 3-buten-2-ones have been synthesized and reacted with acetamidine to yield 5-acetyl-2-methyl-1(H)-imidazoles, 5-substituted pyrimidines, or both.The nature of the product depends on the substituents at position 3 and 4 of th

Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones

There is provided substituted imidazo[1,5-d]-as-triazine-4(3H)-ones and substituted imidazo[1,5-d]-as-triazin-4(3H)-thiones useful as inhibitors of the enzyme cyclic-AMP phosphodiesterase and as broad spectrum herbicides.

Method for the control of undesired plant species using imidazo-as-triazinones and triazine-thiones

This disclosure describes herbicidal methods for the pre- and postemergence control of undesired mono- and dicotyledonous plants using substituted imidazo[1,5-d]-as-triazin-4(3H)-ones and substituted imidazo[1,5-d]-as-triazine-4(3H)-thiones.

IMIDAZO [1,5-d]-AS-TRIAZINE-4(3H)-ONES AND THIONES

There is provided substituted imidazo[1,5-d]-as-triazine-4(3H)-ones and substituted imidazo[1,5-d]-as-triazin-4(3H)-thiones useful as inhibitors of the enzyme cyclic-AMP phosphodiesterase and as broad spectrum herbicides