1004530-38-4Relevant academic research and scientific papers
Synthetic receptors induce anti angiogenic and stress signaling on human first trimester cytotrophoblast cells
Pantho, Ahmed F.,Price, Mason,Zuberi Ashraf,Wajid, Umaima,Khansari, Maryam Emami,Jahan, Afsana,Afroze, Syeda H.,Rhaman, Md Mhahabubur,Johnson, Corey R.,Kuehl, Thomas J.,Hossain, Md. Alamgir,Uddin, Mohammad Nasir
, (2017)
The cytotrophoblast (CTB) cells of the human placenta have membrane receptors that bind certain cardiotonic steroids (CTS) found in blood plasma. One of these, marinobufagenin, is a key factor in the etiology of preeclampsia. Herein, we used synthetic receptors (SR) to study their effectiveness on the angiogenic profile of human first trimester CTB cells. The humanextravillous CTB cells (Sw.71) use in this study were derived from first trimester chorionic villus tissue. Culture media of CTB cells treated with ≥1 nM SR level revealed sFlt-1 (Soluble fms-like tyrosine kinase-1) was significantly increased while VEGF (vascular endothelial growth factor) was significantly decreased in the culture media (*p 1 (Angiotensin II receptor, type 1) and VEGFR-1 (vascular endothelial growth factor receptor 1) receptor expression was significantly downregulated (* p 0.05 for each). Our results show that the anti-proliferative and anti-angiogenic effects of SR on CTB cells are similar to the effects of CTS. The observed anti angiogenic activity of SR on CTB cells demonstrates that the functionalized-urea/thiourea molecules may be useful as potent inhibitors to prevent CTS-induced impairment of CTB cells.
Trapped inorganic phosphate dimer
Lakshminarayanan,Ravikumar,Suresh,Ghosh, Pradyut
, p. 5214 - 5216 (2007)
Single crystal X-ray crystallographic signature of the pentafluorophenyl substituted tripodal urea-based receptor shows formation of a pseudo dimeric cage which also encapsulates a phosphate dimer via numerous hydrogen bonding and anion...π interactions.
Anion complexation of a pentafluorophenyl-substituted tripodal urea receptor in solution and the solid state: selectivity toward phosphate
Ravikumar,Lakshminarayanan,Arunachalam,Suresh,Ghosh, Pradyut
, p. 4160 - 4168 (2009)
The binding and selectivity of halides (spherical) and oxyanions (tetrahedral) toward a recently reported pentafluorophenyl-substituted tripodal urea-based receptor L1 are examined thoroughly in the solid state by single-crystal X-ray crystallo
