1004536-73-5Relevant academic research and scientific papers
Scalable Asymmetric Synthesis of the All Cis Triamino Cyclohexane Core of BMS-813160
La Cruz, Thomas E.,González-Bobes, Francisco,Eastgate, Martin D.,Sfouggatakis, Chris,Zheng, Bin,Kopp, Nathaniel,Xiao, Yi,Fan, Yu,Galindo, Kay A.,Pathirana, Charles,Galella, Michael A.
, p. 1996 - 2011 (2021/09/02)
BMS-813160 is a pharmaceutical entity currently in development at Bristol Myers Squibb. Its defining structural feature is a unique chiral all cis triamino cyclohexane core. Medicinal and process chemistry groups at BMS have previously published synthesis
Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2
Yang, Michael G.,Xiao, Zili,Zhao, Rulin,Tebben, Andrew J.,Wang, Bei,Cherney, Robert J.,Batt, Douglas G.,Brown, Gregory D.,Cvijic, Mary Ellen,Duncia, John V.,Gallela, Michael A.,Gardner, Daniel S.,Khandelwal, Purnima,Malley, Mary F.,Pang, Jian,Rose, Anne V.,Santella, Joseph B.,Sarjeant, Amy A.,Xu, Songmei,Mathur, Arvind,Mandlekar, Sandhya,Vuppugalla, Ragini,Zhao, Qihong,Carter, Percy H.
, p. 969 - 975 (2021/06/25)
To improve the metabolic stability profile of BMS-741672 (1a), we undertook a structure-activity relationship study in our trisubstituted cyclohexylamine series. This ultimately led to the identification of 2d (BMS-753426) as a potent and orally bioavaila
PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE
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, (2019/02/06)
The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employ
CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 21, (2008/06/13)
This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and
