1004558-41-1

Usage

Uses

Used in Organic Synthesis:
Tert-Butyl 7-chloro-1H-indole-1-carboxylate is used as an intermediate in organic synthesis for the preparation of various organic compounds. Its unique structure allows for further functionalization and modification, making it a valuable building block in the synthesis of complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, tert-Butyl 7-chloro-1H-indole-1-carboxylate is used as a starting material for the development of new drugs and pharmaceuticals. Its wide range of biological activities and potential therapeutic effects make it a promising candidate for drug discovery and design.
Used in Drug Development:
Due to its potential use in the development of new drugs and pharmaceuticals, tert-Butyl 7-chloro-1H-indole-1-carboxylate is employed as a key component in drug development processes. Its unique structure and biological activities can be harnessed to create novel therapeutic agents with improved efficacy and selectivity.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 143262-18-4 N-tert-butoxycarbonyl-7-chloro-2,3-dihydroindole 
• 74-88-4 methyl iodide 
• 4248-19-5 tert-butyl carbazate 
• 53924-05-3 7-chloro-1H-indole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 106-95-6 allyl bromide 

Downstream Products

• 1000068-24-5 [1-(tert-butoxycarbonyl)-7-chloro-H-indol-2-yl]boronic acid 

Relevant academic research and scientific papers

Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2- And C3-Borylated Indolines

Indole dearomatization is an important strategy to access indolines: a motif present in a variety of natural products and biologically active molecules. Herein, a method for transition-metal catalyzed regioselective dearomative arylboration of indoles to

Palladium catalyzed tandem alkenyl- and aryl-C-N bond formation: A cascade N-annulation route to 4-, 5-, 6- and 7-chloroindoles

A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of 1-functionalized mono-chloroindoles. 4-, 5-, 6- and 7-Chloroindoles can all be prepared; carbamates, anilines and amines can be employed as the N-nucleophile.

2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

The present invention is directed to 2-phenyl-indole compounds (A), their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in treating a patient suffering from a PGD2-mediated disorder including, but not li

Asymmetric Deprotonations: Lithiation of N-(tert-Butoxycarbonyl)indoline with sec-Butyllithium/ (-)-Sparteine

The asymmetric lithiation of N-Boc indoline (1) with s-BuLi/(-)-sparteine and subsequent substitution provides the 2-substituted N-Boc indolines 3 and 5-11 with excellent enantiomeric ratios and in variable yields. The asymmetric lithiation-substitution sequence with N-Boc-7-chloroindoline (12) provides products 13-19 with good enantiomeric ratios. Mechanistic investigation establishes that the enantioselectivities arise from an initial asymmetric deprotonation to provide the enantioenriched and configurationally stable organolithium intermediates (S)-28 and (S)-29, which react stereoselectively with electrophiles.