100462-43-9 Usage
General Description
Succinic acid-mono-N-phenylsulfonylamide is a chemical compound most commonly known for its use as a reagent in organic synthesis. It is a derivative of succinic acid, with the addition of a phenylsulfonylamide group. SUCCINIC ACID-MONO-N-PHENYLSULFONYLAMIDE is often utilized in the preparation of various pharmaceuticals and biologically active molecules. It is known for its ability to act as a catalyst in a variety of chemical reactions, particularly in the formation of amide bonds. Additionally, succinic acid-mono-N-phenylsulfonylamide has been studied for its potential antimicrobial and antiparasitic properties. Overall, this compound has a wide range of applications in the field of organic chemistry and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 100462-43-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,4,6 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 100462-43:
(8*1)+(7*0)+(6*0)+(5*4)+(4*6)+(3*2)+(2*4)+(1*3)=69
69 % 10 = 9
So 100462-43-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO5S/c12-9(6-7-10(13)14)11-17(15,16)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)(H,13,14)
100462-43-9Relevant articles and documents
Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes
Chong, MuiPhin,Toh, LeeRoy,Tumber, Anthony,Chan, YanYing,Chan, MunChiang,Abboud, Martine I.,Schofield, Christopher J.,Yeoh, KarKheng
, p. 977 - 986 (2021)
There is current interest in developing human hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) inhibitors for the treatment of anemia and other hypoxia-related diseases. We describe the synthesis of 3-carbamoylpropanoic acid derivatives and their evaluation as human PHD-2 inhibitors. MS assays indicated that derivatives with a 3-carbamoylpropanoic acids-containing benzoxazole moiety are inhibitors of PHD-2 with IC50 values of 2.24 μM and 1.32 μM, respectively. However, neither the acids nor their respective ethyl esters were observed to upregulate HIF-1α levels in cells.
