1004651-40-4

Basic information

• Product Name: (E)-1-(4-methylphenyl)-3-{(4-(trifluoromethyl)phenyl)}-2-propen-1-one
• Synonyms: (E)-1-(4-methylphenyl)-3-{(4-(trifluoromethyl)phenyl)}-2-propen-1-one
• CAS NO: 1004651-40-4
• Molecular Weight: 290.285
• Mol File: 1004651-40-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-1-(4-methylphenyl)-3-{(4-(trifluoromethyl)phenyl)}-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-methylphenyl)-3-{(4-(trifluoromethyl)phenyl)}-2-propen-1-one(1004651-40-4)
• EPA Substance Registry System: (E)-1-(4-methylphenyl)-3-{(4-(trifluoromethyl)phenyl)}-2-propen-1-one(1004651-40-4)

Safety Data

• Hazardous Substances Data: 1004651-40-4(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 122-00-9 para-methylacetophenone 
• 851660-03-2 4-trifluoromethylstyrenylboronic acid 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 37009-57-7 2-phenyl-5-p-tolyloxazole 

Relevant articles and documents

Palladium-catalyzed and copper-mediated cross-coupling reaction of aryl- or alkenylboronic acids with acid chlorides under neutral conditions: Efficient synthetic methods for diaryl ketones and chalcones at room temperature

Palladium-catalyzed cross-coupling reaction of aryl- or alkenylboronic acids with acid chlorides in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator in diethyl ether at room temperature under strictly non-basic conditions affords the diaryl ketones or chalcones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible.

Transition-Metal-Free Self-Hydrogen-Transferring Allylic Isomerization

Phenanthroline and tert-butoxide have been established as powerful radical initiators in reactions such as the SRN1-type coupling reactions due to the cooperation of large heteroarenes and a special feature of tert-butoxide. The first phenanthroline-tert-butoxide-catalyzed transition-metal-free allylic isomerization is described. The resulting ketones are key intermediates for indenes. The control experiments rule out the base-promoted allylic anion pathway. The radical pathway is supported by experimental evidence that includes kinetic study, kinetic isotope effect, isotope-labeling experiments, trapping experiments, and EPR experiments.