100466-30-6

Upstream product

• 100466-27-1 4-carboxy-3-nitrobenzyl bromide 
• 100466-28-2 4-carboxy-3-nitrobenzylamine 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 
• 90771-66-7 4-cyano-3-nitrobenzyl acetate 
• 26830-95-5 4-methyl-2-nitrobenzonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100466-29-3 4-(((tert-butoxy carbonyl)amino)methyl)-2-nitrobenzoic acid 

Downstream Products

• 100466-35-1 7-Aminomethyl-1-benzyl-1H-benzo[d][1,3]oxazine-2,4-dione; compound with trifluoro-acetic acid 
• 100466-32-8 N-(tert-butoxycarbonyl)-4-(aminomethyl)-1-benzylisatoic acid 

Relevant academic research and scientific papers

6-, 7-, or 8-Substituted Quinazolinone Derivatives and Compositions Comprising and Methods of Using the Same

Provided are quinazolinone compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Substituted Isatoic Anhydrides: Selective Inactivators of Trypsin-like Serine Proteases

Derivatives of isatoic anhydride were prepared and tested as inhibitors of serine proteases.A number of isatoic anhydrides with positively charged substituents irreversibly inactivated several trypsin-like enzymes and preferentially inactivated trypsin over chymotrypsin.Further selectivity was obtained by introduction of an aromatic group on the N-1 position of isatoic anhydride. 7-(Aminomethyl)-1-benzylisatoic anhydride was prepared and was a selective inactivator of thrombin; thus it is possible to prepare derivatives of isatoic anhydride that are highly enzyme selective without attaching peptide recognition structures.