100466-35-1

Upstream product

• 100466-32-8 N-(tert-butoxycarbonyl)-4-(aminomethyl)-1-benzylisatoic acid 
• 76-05-1 trifluoroacetic acid 
• 26830-95-5 4-methyl-2-nitrobenzonitrile 
• 90771-66-7 4-cyano-3-nitrobenzyl acetate 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 
• 100466-28-2 4-carboxy-3-nitrobenzylamine 
• 100466-27-1 4-carboxy-3-nitrobenzyl bromide 
• 100466-30-6 N-(tert-butoxycarbonyl)-3-amino-4-carboxybenzylamine 
• 100466-29-3 4-(((tert-butoxy carbonyl)amino)methyl)-2-nitrobenzoic acid 
• 100466-31-7 N-(tert-butoxycarbonyl)-7-(aminomethyl)isatoic anhydride 

Relevant academic research and scientific papers

Substituted Isatoic Anhydrides: Selective Inactivators of Trypsin-like Serine Proteases

Derivatives of isatoic anhydride were prepared and tested as inhibitors of serine proteases.A number of isatoic anhydrides with positively charged substituents irreversibly inactivated several trypsin-like enzymes and preferentially inactivated trypsin over chymotrypsin.Further selectivity was obtained by introduction of an aromatic group on the N-1 position of isatoic anhydride. 7-(Aminomethyl)-1-benzylisatoic anhydride was prepared and was a selective inactivator of thrombin; thus it is possible to prepare derivatives of isatoic anhydride that are highly enzyme selective without attaching peptide recognition structures.