100475-40-9Relevant academic research and scientific papers
Friedel-Crafts Reaction of 2-Methylfuran with Saturated and α,β-Unsaturated Acid Anhydrides
Scholz, Stefan,Marschall-Weyerstahl, Helga,Weyerstahl, Peter
, p. 1935 - 1950 (2007/10/02)
2-Methylfuran (5) reacts with the saturated acid anhydrides 16 - 26 in the presence of SnCl4 to give the 2-acyl-5-methylfurans 37 - 47 selectively.The unsaturated anhydrides 27 - 32, however, yield mixtures which only in the case of senecioic acid anhydride (29) contain the respective primary product 48.Subsequent reactions lead to the addition products 55 (from 27) and 56 (from 29), and to (E,Z)-mixtures of their enol esters 57 - 62 which could partially be separated and assigned. - The olfactory properties of 2, 37 - 48, 50, 52, and 53 were investigated.
