34876-10-3

Usage

Uses

Used in Pharmaceutical Industry:
3-Methylbut-2-enoic anhydride is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Methylbut-2-enoic anhydride is utilized as a precursor in the production of agrochemicals, aiding in the creation of more effective pesticides and other agricultural chemicals.
Used in Dye and Perfume Industry:
3-Methylbut-2-enoic anhydride is employed as a building block in the synthesis of dyes and perfumes, enhancing the color and fragrance properties of these products.
Used as a Reagent in Chemical Reactions:
3-Methylbut-2-enoic anhydride is used as a reagent in various chemical reactions, facilitating the synthesis of other organic compounds and contributing to the advancement of organic chemistry.
Safety Considerations:
Due to its flammable nature and potential to cause skin and eye irritation, 3-Methylbut-2-enoic anhydride should be handled with care in a controlled environment to ensure the safety of workers and the integrity of the chemical processes involved.

InChI:InChI=1/C10H14O3/c1-7(2)5-9(11)13-10(12)6-8(3)4/h5-6H,1-4H3

Upstream product

• 541-47-9 3-Methylbutenoic acid 
• 50785-07-4 4-isopropylidene-2,2-diphenylcyclobutan-1-one 
• 3350-78-5 3,3-Dimethylacryloyl chloride 

Downstream Products

• 5945-67-5 3-Methyl-1-(5-methyl-2-furanyl)-2-buten-1-on 
• 100475-40-9 3-Methyl-1,3-bis(5-methyl-2-furanyl)-1-butanon 
• 100475-43-2 (E)-3-Methyl-2-butensaeure-<3-methyl-1,3-bis(5-methyl-2-furanyl)-1-butenyl>ester 
• 51637-55-9 isopropenylketene 
• 115-11-7 isobutene 
• 76837-21-3 2-methyl-4-oxo-6-phenyl-2-hexene 
• 56500-47-1 octyl 3-methyl-2-butenoate 
• 84346-76-9 4'-methoxyphenyl 3-methylbut-2-enoate 
• 20886-47-9 N,3-dimethyl-N-phenylbut-2-enamide 
• 83632-87-5 3-Methyl-1-(2-methyl-cyclohex-2-enyl)-but-2-en-1-one 

Relevant academic research and scientific papers

Photoinduced electron-transfer, pyrolyses, and direct irradiation reactions of 2-methylenecyclobutanones: Regioselective bond cleavage depends on the substituents and the method of activation

The regioselectivity of bond cleavage and the subsequent reactivity of 4-methylene-3,3-dimethyl-2,2-diphenylcyclobutan-1-one (5) and 4-isopropylidene-2,2-diphenylcyclobutan-1-one (6) in photoinduced electron transfer, pyrolysis, and direct irradiation rea

Direct Acylation of C(sp3)-H Bonds Enabled by Nickel and Photoredox Catalysis

Using nickel and photoredox catalysis, the direct functionalization of C(sp3)-H bonds of N-aryl amines by acyl electrophiles is described. The method affords a diverse range of α-amino ketones at room temperature and is amenable to late-stage coupling of complex and biologically relevant groups. C(sp3)-H activation occurs by photoredox-mediated oxidation to generate α-amino radicals which are intercepted by nickel in catalytic C(sp3)-C coupling. The merger of these two modes of catalysis leverages nickel's unique properties in alkyl cross-coupling while avoiding limitations commonly associated with transition-metal-mediated C(sp3)-H activation, including requirements for chelating directing groups and high reaction temperatures. Teamwork: The direct functionalization of C(sp3)-H bonds of N-aryl amines by acyl electrophiles is achieved, thus affording a diverse range of α-amino ketones at room temperature. C(sp3)-H activation occurs by photoredox-mediated oxidation to generate α-amino radicals which are intercepted by nickel in catalytic C(sp3)-C coupling.

PROCESS FOR PRODUCING ACID ANHYDRIDE

According to the present invention there is provided a process for producing an acid anhydride by reacting a carboxylic acid, preferably a carboxylic acid having a polymerizable group, with a sulfonyl halide compound in the presence of a tertiary amine or in the presence of a tertiary amine and an inorganic base, wherein the tertiary amine or the tertiary amine and the inorganic base are used in an amount of 0.9 to 1.2 equivalents relative to the acid generated from the sulfonyl halide compound.

Facile synthesis of carboxylic anhydrides using 4,5-dichloro-2-[(4-nitrophenyl)sulfonyl]pyridazin-3(2H)-one

A novel and facile synthesis of carboxylic anhydrides from carboxylic acid using 4,5-dichloro-2-[(4-nitrophenyl)sulfonyl]pyridazin-3(2H)-one (2) is presented. Treatment of aliphatic or aromatic carboxylic acids with 2 in the presence of base in organic solvents gave the corresponding anhydrides in good or excellent yields.

A convenient method for synthesis of symmetrical acid anhydrides from carboxylic acids with trichloroacetonitrile and triphenylphosphine

Various carboxylic acids are converted into the corresponding carboxylic acid anhydrides treated with trichloroacetonitrile and triphenylphosphine in the presence of triethylamine at room temperature.

Asymmetric Solid-Phase Synthesis of (3′R,4′R)-Di-O-cis-acyl 3-Carboxyl Khellactones

Matrix Presented We describe a practical parallel synthesis of (3′R,4′R)-di-O-cis-acyl 3-carboxyl khellactones on a solid phase in high yield. The highlights of this synthesis include a Knoevenagel condensation, asymmetric dihydroxylation, catalyzed acylation, and product cleavage from the solid support.