1004758-01-3Relevant academic research and scientific papers
Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672
Yang, Michael G.,Xiao, Zili,Cherney, Robert J.,Tebben, Andrew J.,Batt, Douglas G.,Brown, Gregory D.,Chen, Jing,Cvijic, Mary Ellen,Dabros, Marta,Duncia, John V.,Galella, Michael,Gardner, Daniel S.,Khandelwal, Purnima,Ko, Soo S.,Malley, Mary F.,Mo, Ruowei,Pang, Jian,Rose, Anne V.,Santella, Joseph B.,Shi, Hong,Srivastava, Anurag,Traeger, Sarah C.,Wang, Bei,Xu, Songmei,Zhao, Rulin,Barrish, Joel C.,Mandlekar, Sandhya,Zhao, Qihong,Carter, Percy H.
, p. 300 - 305 (2019/03/12)
We encountered a dilemma in the course of studying a series of antagonists of the G-protein coupled receptor CC chemokine receptor-2 (CCR2): compounds with polar C3 side chains exhibited good ion channel selectivity but poor oral bioavailability, whereas
Stereoselective Bulk Synthesis of CCR2 Antagonist BMS-741672: Assembly of an All-cis (S,R,R)-1,2,4-Triaminocyclohexane (TACH) Core via Sequential Heterogeneous Asymmetric Hydrogenations
Deerberg, Joerg,Prasad, Siva J.,Sfouggatakis, Chris,Eastgate, Martin D.,Fan, Yu,Chidambaram, Ramakrishnan,Sharma, Praveen,Li, Li,Schild, Richard,Müslehiddino?lu, Jale,Chung, Hyei-Jha,Leung, Simon,Rosso, Victor
, p. 1949 - 1966 (2017/02/10)
A concise bulk synthesis of stereochemically complex CCR2 antagonist BMS-741672 is reported. A distinct structural feature is the chiral all-cis 1,2,4-triaminocyclohexane (TACH) core, which was assembled through consecutive stereocontrolled heterogeneous
CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 11, (2008/06/13)
This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and
