746671-17-0

Basic information

• Product Name: 6-Azabicyclo[3.2.1]octane-6-carboxylic acid, 7-oxo-2-[(3S)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-pyrrolidinyl]-, 1,1-dimethylethyl ester, (1R,2S,5R)-
• CAS NO: 746671-17-0
• Molecular Formula: C24H31N3O6
• Molecular Weight: 457.527
• Mol File: 746671-17-0.mol

Chemical Properties

• CAS DataBase Reference: 6-Azabicyclo[3.2.1]octane-6-carboxylic acid, 7-oxo-2-[(3S)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-pyrrolidinyl]-, 1,1-dimethylethyl ester, (1R,2S,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Azabicyclo[3.2.1]octane-6-carboxylic acid, 7-oxo-2-[(3S)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-pyrrolidinyl]-, 1,1-dimethylethyl ester, (1R,2S,5R)-(746671-17-0)
• EPA Substance Registry System: 6-Azabicyclo[3.2.1]octane-6-carboxylic acid, 7-oxo-2-[(3S)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-pyrrolidinyl]-, 1,1-dimethylethyl ester, (1R,2S,5R)-(746671-17-0)

Safety Data

• Hazardous Substances Data: 746671-17-0(Hazardous Substances Data)

Upstream product

• 746671-16-9 tert-butyl (1R,2S,5R)-2-amino-7-oxo-6-azabicyclo[3.2.1]octane-6-carboxylate 
• 746670-91-7 (1R,2S,5R)-tert-butyl 2-(benzyloxycarbonylamino)-7-oxo-6-azabicyclo[3.2.1]octane-6-carboxylate 
• 847955-65-1 tert-butyl (1R,2S,5R)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-(methylthio)butanamido)-7-oxo-6-azabicyclo[3.2.1]octane-6-carboxylate 
• 1004536-58-6 C₂₆H₃₈N₃O₆S⁽¹⁺⁾*I^(1-) 

Downstream Products

• 1004536-61-1 (1R,2S,5R)-2-((S)-3-(((benzyloxy)carbonyl)amino)-2-oxopyrrolidin-1-yl)-5-((tertbutoxycarbonyl)amino)cyclohexane-1-carboxylic acid 
• 746671-23-8 tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(hydroxymethyl)cyclohexylcarbamate 
• 848002-41-5 (1S,2S,5R)-ethyl 2-((S)-3-(benzyloxycarbonylamino)-2-oxopyrrolidin-1-yl)-5-(tert-butoxycarbonylamino)cyclohexanecarboxylate 
• 1004536-63-3 (1R,2S,5R)-2-((S)-3-(benzyloxycarbonylamino)-2-oxopyrrolidin-1-yl)-5-(tert-butoxycarbonylamino)cyclohexanecarboxamide 
• 1004536-65-5 tert-butyl ((1R,3R,4S)-3-acetamido-4-((S)-3-(((benzyloxy)carbonyl)amino)-2-oxopyrrolidin-1-yl)cyclohexyl)carbamate 
• 1004536-68-8 benzyl ((S)-1-((1S,2R,4R)-2-acetamido-4-aminocyclohexyl)-2-oxopyrrolidin-3-yl)carbamate 
• 1004758-00-2 benzyl (S)-1-((1S,2R,4R)-2-acetamido-4-(isopropylamino)cyclohexyl)-2-oxopyrrolidin-3-ylcarbamate 
• 1004758-01-3 benzyl (S)-1-((1S,2R,4R)-2-acetamido-4-(isopropyl-(methyl)amino)cyclohexyl)-2-oxopyrrolidin-3-ylcarbamate 
• 1004758-02-4 N-((1R,2S,5R)-2-((S)-3-amino-2-oxopyrrolidin-1-yl)-5-(isopropyl(methyl)amino)cyclohexyl)acetamide 

Relevant articles and documents

Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672

We encountered a dilemma in the course of studying a series of antagonists of the G-protein coupled receptor CC chemokine receptor-2 (CCR2): compounds with polar C3 side chains exhibited good ion channel selectivity but poor oral bioavailability, whereas

CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and

Cyclic derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.

Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.