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100488-87-7

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100488-87-7 Usage

Description

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively. It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid , histamine, bradykinin , or isoproterenol . CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.

Chemical Properties

Pale-Yelow Solid

Uses

Competitive PAF receptor antagonist. Inhibits PAF induced human platelet aggregation. Inhibits PAF induced hypotension and lethality.

Check Digit Verification of cas no

The CAS Registry Mumber 100488-87-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,4,8 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 100488-87:
(8*1)+(7*0)+(6*0)+(5*4)+(4*8)+(3*8)+(2*8)+(1*7)=107
107 % 10 = 7
So 100488-87-7 is a valid CAS Registry Number.
InChI:InChI=1/C34H59N3O6.ClH/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-25-35-33(39)42-28-32(41-4)29-43-34(40)37(30(3)38)27-31-24-21-23-26-36(31)6-2;/h21,23-24,26,32H,5-20,22,25,27-29H2,1-4H3;1H

100488-87-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-<propoxy>carbonyl>amino>methyl>-1-ethylpyridinium chloride

1.2 Other means of identification

Product number -
Other names 2-{N-acetyl-N-[({2-methoxy-3-[(octadecylcarbamoyl)oxy]propoxy}carbonyl)amino]methyl}-1-ethylpyridinium chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100488-87-7 SDS

100488-87-7Downstream Products

100488-87-7Related news

Effects of the PAF-analog and -antagonist CV-6209 (cas 100488-87-7) on cultured human glioma cell lines07/29/2019

Cell lines of human glioma (U-343 MGa and U-251 MG) and human glia (U-533 CG) origin were cultured as monolayers and exposed to CV-6209, an alkyl-phospholipid analog and antagonist of platelet activating factor. This drug had very potent antiproliferative effects on the studied human glioma cell...detailed

100488-87-7Relevant articles and documents

Platelet activating factor antagonists: Synthesis and structure-activity studies of novel PAF analogues modified in the phosphorylcholine moiety

Takatani,Yoshioka,Tasaka,Terashita,Imura,Nishikawa,Tsushima

, p. 56 - 64 (2007/10/02)

New analogues of platelet activating factor (PAF), in which the phosphate and trimethylammonium moieties were replaced with an acylcarbamoyl moiety and a quaternary cyclic ammonium group, were synthesized. Their biological activities as PAF antagonists we

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