100488-87-7 Usage
Description
CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively. It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid , histamine, bradykinin , or isoproterenol . CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.
Chemical Properties
Pale-Yelow Solid
Uses
Competitive PAF receptor antagonist. Inhibits PAF induced human platelet aggregation. Inhibits PAF induced hypotension and lethality.
Check Digit Verification of cas no
The CAS Registry Mumber 100488-87-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,4,8 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 100488-87:
(8*1)+(7*0)+(6*0)+(5*4)+(4*8)+(3*8)+(2*8)+(1*7)=107
107 % 10 = 7
So 100488-87-7 is a valid CAS Registry Number.
InChI:InChI=1/C34H59N3O6.ClH/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-25-35-33(39)42-28-32(41-4)29-43-34(40)37(30(3)38)27-31-24-21-23-26-36(31)6-2;/h21,23-24,26,32H,5-20,22,25,27-29H2,1-4H3;1H
100488-87-7Relevant articles and documents
Platelet activating factor antagonists: Synthesis and structure-activity studies of novel PAF analogues modified in the phosphorylcholine moiety
Takatani,Yoshioka,Tasaka,Terashita,Imura,Nishikawa,Tsushima
, p. 56 - 64 (2007/10/02)
New analogues of platelet activating factor (PAF), in which the phosphate and trimethylammonium moieties were replaced with an acylcarbamoyl moiety and a quaternary cyclic ammonium group, were synthesized. Their biological activities as PAF antagonists we