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6-Fluoro-1-(4-fluoro-phenyl)-7-(3-hydroxy-pyrrolidin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester is a complex organic compound with a molecular formula of C20H18F2N2O4. It is characterized by the presence of a naphthyridine ring system, which is a fused bicyclic structure consisting of a pyridine and a pyridine-like ring. The compound features a fluorine atom at the 6-position, a 4-fluoro-phenyl group at the 1-position, and a 3-hydroxy-pyrrolidin-1-yl group at the 7-position. The 4-oxo group indicates the presence of a carbonyl group, and the compound is further modified by an ethyl ester group attached to the 3-carboxylic acid. This chemical structure suggests potential applications in medicinal chemistry, possibly as a precursor or intermediate in the synthesis of pharmaceuticals, given its intricate arrangement of functional groups.

100491-95-0

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100491-95-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 100491-95-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,4,9 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 100491-95:
(8*1)+(7*0)+(6*0)+(5*4)+(4*9)+(3*1)+(2*9)+(1*5)=90
90 % 10 = 0
So 100491-95-0 is a valid CAS Registry Number.

100491-95-0Downstream Products

100491-95-0Relevant academic research and scientific papers

Synthesis and Structure-Activity Relationships of New Arylfluoronaphthyridine Antibacterial Agents

Chu, Daniel T. W.,Fernandes, Prabhavathi B.,Claiborne, Akiyo K.,Gracey, Eugene H.,Pernet, Andre G.

, p. 2364 - 2369 (2007/10/02)

Novel arylfluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid have been prepared and their antibacterial activity evaluated.These derivatives are characterized by having a fluorine atom at 6-position, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.The in vitro antibacterial potency is greatest when the 1-substituent is either p-fluorophenyl or o,p-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-amino-1-pyrrolidinyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (38) was found to possess excellent in vitro potency and in vivo efficacy.

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