1004994-84-6Relevant articles and documents
Synthesis of a 1α-C-methyl analogue of 25-hydroxyvitamin D3: interaction with a mutant vitamin D receptor Arg274Leu
Honzawa, Shinobu,Takahashi, Naoyuki,Yamashita, Atsushi,Sugiura, Takayuki,Kurihara, Masaaki,Arai, Midori A.,Kato, Shigeaki,Kittaka, Atsushi
experimental part, p. 7135 - 7145 (2009/12/06)
Vitamin D3 analogues have been developed for a mutant vitamin D receptor (VDR), Arg274Leu. The mutant VDR has a mutation at Arg274, which forms an important hydrogen bond with 1α-OH of 1α,25-dihydroxyvitamin D3 to anchor the ligand t