1005006-72-3Relevant academic research and scientific papers
Carbocyclic 4′-epi-formycin
Zhou, Jian,Yang, Minmin,Akdag, Akin,Wang, Haisheng,Schneller, Stewart W.
, p. 433 - 438 (2008/09/16)
Formycin is a naturally occurring biologically responsive C-nucleoside. In pursuing the design and syntheses of novel C-nucleosides, convenient access to carbocyclic C-nucleosides based on the formycin framework was a goal. One such target was carbocyclic 4′-epi-formycin (4). This compound is reported via a procedure based on an asymmetric aldol/ring closure metathesis strategy. To provide a preliminary glimpse into the biological characterization of 4 an antiviral assay was conducted. Target 4 was found to be inactive and to lack cytotoxicity to the host cells.
