1005135-44-3Relevant academic research and scientific papers
Benzoyl peroxide promoted radical ortho-alkylation of nitrogen heteroaromatics with simple alkanes and alcohols
Fang, Lei,Chen, Liangshun,Yu, Jianjun,Wang, Limin
supporting information, p. 1910 - 1914 (2015/03/18)
A catalytic amount of benzoyl peroxide (BPO)-initiated cross-dehydrogenative coupling reaction of N-iminopyridine ylides with simple alkanes and alcohols leads to the corresponding 2-alkylpyridines with high regioselectivity in moderate to good yields without an additional reduction step to remove the activated group. A catalytic amount of benzoyl peroxide (BPO)-initiated cross-dehydrogenative coupling reaction of N-iminopyridine ylides with simple alkanes and alcohols has been developed. The strategy allowed convenient access to various 2-alkylpyridines in moderate to good yields without an additional reduction step to remove the activated group.
Silver-catalyzed direct C-H arylation of N -iminopyridinium ylides with arylboronic acids
Fang, Lei,Shi, Xiaoyun,Chen, Liangshun,Yu, Jianjun,Wang, Limin
supporting information, p. 1413 - 1418 (2014/06/23)
A novel direct C-H arylation of N-iminopyridinium ylides with arylboronic acids has been developed. This reaction is performed at ambient temperature using inexpensive reagents: catalytic silver nitrate in the presence of potassium persulfate co-oxidant and give pyridyl arylation derivatives in moderate to good yields.
Palladium-catalyzed direct C-H arylation of N-iminopyridinium ylides: Application to the synthesis of (±)-anabasine
Larivee, Alexandre,Mousseau, James J.,Charette, Andre B.
, p. 52 - 54 (2008/09/20)
Palladium-catalyzed direct C-H arylation of N-iminopyridinium ylides provides a powerful and versatile method for the synthesis of functionalized piperidines in good yields. Chemoselective functionalization of the pyridinium ring in the presence of a pyridine substituent is possible as exemplified by the expedient synthesis of anabasine in 61% overall yield over three steps. Copyright
