100515-82-0

Upstream product

• 23336-68-7 triethylammonium-2-N-morpholino-dithiocarbamate 
• 598-72-1 2-Bromopropionic acid 
• 16022-65-4 potassium morpholine-4-dithiocarbamate 
• 598-78-7 (R,S)-2-chloropropionic acid 
• 873-58-5 sodium N-morpholinocarbamodithioate 
• 16987-02-3 L-2-chloropropionic acid sodium salt 

Relevant academic research and scientific papers

Mesoionic 5-alkyl-1,3-dithiolium-4-thiolates: Synthesis and brine shrimp toxicity

A series of twelve 1,3-dithiolium-4-thiolate mesoionic compounds were synthesized and characterized. The synthetical approach starting from α-bromoalkanoic acids to obtain the corresponding 2-N-morpholino-dithiocarbamoyl-carboxylic acids that by on-pot reaction with carbon disulfide and acetic anhydride in triethylamine formed not isolate intermediates, 1,3-dithiolium-4-olates. After, the 2-N-morpholino-5-alkyl-1,3-dithiolium-4-thiolates were obtained by retro 1,3-dipolar addition reactions. The alkyl moiety linked to C-5 of heterocyclic ring permitted the increase of the hydrophobic character and this effect was evaluated on Artemia salina lethality. The results indicated a bell-shaped relationship between the number of carbon of side chain in mesoionic derivatives and LD50 in brine shrimp toxicity assays.

Synthesis and Physical Properties of Novel 1,3-Dithiolylium-4-methanides and 1,3-Thiazolium-5-methanides

The synthesis and physical properties of the novel title compounds of type 9 from carboxylic acid derivatives 3 and CH acidic compounds 4 are described.