16022-65-4

Basic information

• Product Name: Morpholine-4-carbodithioic acid potassium salt
• Synonyms: 4-Morpholinedithiocarboxylic acid potassium salt;Morpholine-4-carbodithioic acid potassium salt
• CAS NO: 16022-65-4
• Molecular Formula: C₅H₈NOS₂*K
• Molecular Weight: 201.3514
• Mol File: 16022-65-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 239°Cat760mmHg
• Flash Point: 98.4°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.0411mmHg at 25°C
• CAS DataBase Reference: Morpholine-4-carbodithioic acid potassium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine-4-carbodithioic acid potassium salt(16022-65-4)
• EPA Substance Registry System: Morpholine-4-carbodithioic acid potassium salt(16022-65-4)

Safety Data

• Hazardous Substances Data: 16022-65-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H9NOS2.K/c8-5(9)6-1-3-7-4-2-6;/h1-4H2,(H,8,9);/q;+1/p-1

Upstream product

• 110-91-8 morpholine 
• 75-15-0 carbon disulfide 

Downstream Products

• 100515-82-0 2-N-morpholino-dithiocarbamoyl-propanoic acid 
• 729-46-4 4,4'-(dithiodicarbonothioyl)dimorpholine 

Relevant articles and documents

Radioprotective activity of new dithiocarbamic acid salts

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Synthesis, chemical characterization and cancer cell growth-inhibitory activities of Cu(ii) and Ru(iii) aliphatic and aromatic dithiocarbamato complexes

In this paper, we focused on the analysis of the effects mediated by different cyclic dithiocarbamic ligands (DTC) on three classes of antiproliferative coordination compounds, namely, Ru(iii) complexes with the general formulae [Ru(DTC)3] and [Ru2(DTC)5]Cl, and the neutral Cu(ii) derivatives of the type [Cu(DTC)2]. In particular, we present the synthesis and characterization of a library of total 23 coordination compounds containing Ru(iii) or Cu(ii) as the biologically-active metal center and two or more dithiocarbamato (DTC) ligands derived from cyclic amines (aliphatic or aromatic). Several techniques including elemental analysis, X-ray crystallography, ESI-MS, 1H-NMR spectroscopy, FT-IR and UV-Vis spectrophotometry were used to characterize the compounds, which highlighted the different electronic behaviors generated by the substituents within the DTC moiety. Moreover, the synthesized compounds were tested for their stability in order to investigate their antiproliferative activity against 3 human cancer cell lines, namely, HeLa, HepG2 and HepG2/SB3. In particular, HepG2/SB3 was chosen for its aggressiveness due to upregulation of the anti-apoptotic protein SerpinB3. Finally, the most promising compounds are studied in terms of log?P. Overall, the results reveal the drug-likeness of some of the derivatives of copper(ii) and ruthenium(iii).

Synthesis and antitumor activity of tetrahydrocarbazole hybridized with dithioate derivatives

The present study reported the synthesis of tetrahydrocarbazoles hybridized with dithioate derivatives. Three series were synthesized namely alkyl dithiocarbonates (4a-d), heterocyclic dithiocarbamates (6a-g) and dialkyl dithiocarbamate (7). The synthesized compounds were tested in vitro on human breast adenocarcinoma cell line (MCF7) and the human colon tumor cell line (HCT116). Most of the synthesized compounds exploited potent antitumor activity, especially compound 6f [4-chlorophenylpiperazine derivative], which showed cytotoxic activity against MCF7 superior to doxorubicin with IC50 value of 7.24 nM/mL.