1005346-86-0Relevant academic research and scientific papers
Direct one-pot synthesis of phenanthrenes via Suzuki-Miyaura coupling/aldol condensation cascade reaction
Young, Ha Kim,Lee, Hyuk,Yeong, Joon Kim,Bum, Tae Kim,Heo, Jung-Nyoung
, p. 495 - 501 (2008)
(Chemical Equation Presented) We have developed an efficient cascade reaction, a Suzuki-Miyaura coupling followed by an aldol condensation, for the construction of phenanthrene derivatives using microwave irradiation. For example, the reaction of methyl 2-bromophenylacetamide with 2- formylphenylboronic acid in the presence of a palladium catalyst and a base provided a biaryl intermediate, which underwent in situ cyclization to afford the corresponding phenanthrene in high yield.
