1005347-27-2Relevant academic research and scientific papers
Synthesis and characterization of a pair of O-: Fac /O- mer 12-P-6 alkyloxaphosphates with a P-O-C-C four-membered ring
Jiang, Xin-Dong,Toya, Yuya,Matsukawa, Shiro,Kojima, Satoshi,Jimenez-Halla, J. Oscar C.,Shang, Rong,Nakamoto, Masaaki,Yamamoto, Yohsuke
, p. 3466 - 3472 (2019/03/28)
Structurally characterized hexacoordinate organophosphorus compounds remain rare due to their highly reactive nature and thermal instability. Herein we report the first synthesis of a pair of O-facial and O-meridional hexacoordinate oxaphosphates (5B and 5D) obtained from the O-apical and O-equatorial β-hydroxyalkylphosphoranes 3 and 4. This was achieved by using the bulky C2F5-groups on the ortho-substituted aryl backbone. Calculations of the relative energies of possible isomers indicate 5B and 5D are thermodynamic products. Although the mechanisms of their formation and the determining factor of stereo-selectivity are still unclear, their isolation and structure conformation contributes to a formulation of a viable strategy for diastereoselective synthesis of heteroleptic hexacoordinate organophosphates.
