1005347-33-0Relevant academic research and scientific papers
Some reactions of O-equatorial spirophosphoranes bearing the bidentate ligand based on decafluoro-3-phenyl-3-pentanol
Jiang, Xin-Dong,Matsukawa, Shiro,Yamamichi, Hideaki,Yamamoto, Yohsuke
experimental part, p. 805 - 824 (2009/09/08)
Some reactions of O-equatorial and O-apical methylphosphoranes bearing two bidentateligands consisted of1,1,1,2,2,4A,5,5,5-decafluoro-3-phenyl-3-pentanol were examined. Not only the O-apical phosphorane, but also the O-equatorial isomer did not react with MeLi as a nucleophile at the phosphorus center. This should be due to the steric bulkiness of the C2F5 group. For both isomers, deprotonation at the methyl group was achieved using Superbase (t-BuOK/n-BuLi) to give the corresponding α-anion, which was treated with several electrophiles to afford new phosphorane derivatives. The O-equatorial and O-apical phosphoranes having a β-hydroxyethyl group as the monodentate ligand were synthesized. It was found that under basic conditions,. the O-apical phosphorane could be converted into the O-equatorial isomer via hexacoordinate phosphate intermediates.
