1005386-08-2Relevant academic research and scientific papers
Concise assembly of highly substituted furan-fused 1,4-thiazepines and their Diels-Alder reactions with benzynes
Ding, Hanfeng,Zhang, Yiping,Bian, Ming,Yao, Weijun,Ma, Cheng
, p. 578 - 584 (2008/09/17)
(Chemical Equation Presented) A facile and highly efficient three-component reaction of thiazole or benzothiazole carbenes, disubstituted ketenes, and activated alkynes is disclosed. With this methodology, a poly substituted ring system containing furo[2,3-c]thiazepine core can be constructed from simple and readily accessible starting materials in good yields. The scope and limitation of this transformation were investigated in detail by using various thiazole carbene, ketene, and alkyne components. Furthermore, the synthetic utilities of these unique polyheterocyclic compounds were demonstrated via their Diels-Alder reactions with benzynes to furnish thiazepine-fused 7-oxanorbornadiene derivatives in excellent yields.
Thiazepine moiety-controlled regioselective rearrangements of 7-oxanorbornadiene derivatives
Ding, Hanfeng,Zhang, Yiping,Yao, Weijun,Xu, Duanjun,Ma, Cheng
supporting information; experimental part, p. 5797 - 5799 (2009/04/13)
We have discovered thiazepine moiety-controlled regioselective skeletal rearrangements of 7-oxanorbornadiene derivatives (2, 7 and 12) with high regioselectivity and/or diastereoselectivity in the presence of Bronsted acid. The Royal Society of Chemistry.
