923286-35-5Relevant academic research and scientific papers
Concise assembly of highly substituted furan-fused 1,4-thiazepines and their Diels-Alder reactions with benzynes
Ding, Hanfeng,Zhang, Yiping,Bian, Ming,Yao, Weijun,Ma, Cheng
, p. 578 - 584 (2008)
(Chemical Equation Presented) A facile and highly efficient three-component reaction of thiazole or benzothiazole carbenes, disubstituted ketenes, and activated alkynes is disclosed. With this methodology, a poly substituted ring system containing furo[2,3-c]thiazepine core can be constructed from simple and readily accessible starting materials in good yields. The scope and limitation of this transformation were investigated in detail by using various thiazole carbene, ketene, and alkyne components. Furthermore, the synthetic utilities of these unique polyheterocyclic compounds were demonstrated via their Diels-Alder reactions with benzynes to furnish thiazepine-fused 7-oxanorbornadiene derivatives in excellent yields.
A ring-expansion methodology involving multicomponent reactions: Highly efficient access to polysubstituted furan-fused 1,4-thiazepine derivatives
Ma, Cheng,Ding, Hanfeng,Zhang, Yiping,Bian, Ming
, p. 7793 - 7797 (2006)
(Chemical Equation Presented) Tri-ed and tested: Ring expansion processes were observed in the novel three-component reaction of thiazolium salts 1, 1,1-disubstituted ketenes 2 (generated in situ), and activated alkynes (see scheme, EWG = electron-withdrawing group). This protocol allows highly efficient assembly of unique furan-fused 1,4-thiazepine derivatives from simple and readily accessible starting materials.
